Publications by authors named "Iwata E"

In this study, we aimed to identify risk factors that predict the postoperative need for advanced or prolonged airway management in patients with severe odontogenic deep neck infections (DNIs). This retrospective case-control study included patients of both sexes aged ≥ 18 years who had undergone surgical drainage including debridement of necrotic tissues of odontogenic deep neck abscesses and necrotizing soft tissue infection under general anesthesia between April 2016 and September 2023 at a single center. The patients' characteristics, laboratory tests, and computed tomography (CT) findings were analyzed and compared between the difficult postoperative airway group, which required prolonged intubation or tracheostomy, and the short-term intubation group.

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Background: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome.

Methods: This study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction.

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Purpose: Mandibular wisdom teeth can occasionally cause infections, which can progress to severe deep neck infections (DNIs) including deep neck abscesses or necrotizing soft tissue infections, which are fatal. This study aimed to identify the radiographic characteristics of mandibular wisdom teeth that developed severe DNIs.

Methods: This study included patients who were admitted for the treatment of severe mandibular wisdom tooth infection between July 2012 and June 2024 at a single center.

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Article Synopsis
  • The study aimed to develop guidelines for antibiotic use during tooth extractions in cancer patients on denosumab, as there's a risk of medication-related osteonecrosis of the jaw (MRONJ).
  • It analyzed 68 cancer patients' antibiotic administration practices and their correlation with MRONJ after tooth extractions over a 10-year period.
  • Results showed a lot of inconsistency in antibiotic usage among hospitals, with amoxicillin being the most common; however, no significant link between MRONJ occurrence and the dosage or duration of amoxicillin was identified, suggesting a single preoperative dose may be sufficient.
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Background: The situation of Helicobacter pylori eradication therapy has been changing over time, owing to increases in antimicrobial-resistant strains, lifestyle improvements, and changes in indications for eradication. In Japan, eradication therapy is now available to all H. pylori-positive patients under the medical insurance system, and the potassium-competitive acid blocker vonoprazan has been used for eradication from 2015.

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In the present study, the authors examined the association between gastric bacterial infection and gastric endoscopic findings in ()-negative patients. The subjects were 105 -negative patients. The mean age was 72.

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Noma horses are native Japanese horses. Health checkups revealed that many Noma horses developed dermatitis during summer, which subsided in winter. Seasonal development and signs of itching, suggestive of allergic dermatitis, were observed.

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Article Synopsis
  • Patients on hemodialysis (HD) are at risk for gastrointestinal diseases, and while eliminating Helicobacter pylori is advised to prevent gastric cancer, the best treatment approach and dosages for these patients remain unclear due to potential side effects and renal risks.
  • Some drugs used in eradication therapy, especially amoxicillin, can worsen kidney function, necessitating careful adjustment of dosages in HD patients.
  • Recent studies show that reducing drug dosages by 1/2 to 1/3 can minimize adverse effects while maintaining similar rates of successful eradication compared to healthy individuals, highlighting the need for optimized treatment regimens for this population.
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Background: Map-like redness is a newly identified endoscopic risk factor for gastric cancer in patients who received Helicobacter pylori eradication therapy. However, the incidence rate of map-like redness in patients who received eradication, and the risk factors for the development of map-like redness remain unclear. We hence aimed to investigate the incidence rate of map-like redness at 1-year post H.

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Plasma or serum amino acids are used to evaluate nutritional status and metabolic disorders. In this study, we aimed to set reference values of serum amino acid concentrations in the Noma horse, a Japanese native horse. Thirty-one horses were classified into six age groups: neonatal foal (0-4 days), foal (0.

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Helicobacter pylori eradication therapy reduces the risk of gastric cancer. However, it is unclear whether the severity of risk factors for gastric cancer such as atrophy and intestinal metaplasia are reduced after eradication in the long term. We aimed to study long-term changes in endoscopic risk factors for gastric cancer up to 20 years post-eradication.

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Background: Evidence has been mixed regarding the effect of topical vancomycin (VCM) powder in reducing surgical site infection (SSI).

Aim: To clarify the effect of topical VCM powder for the prevention of SSI in major orthopaedic surgeries.

Methods: The MEDLINE, Embase, CENTRAL, ICTRP, and ClinicalTrials.

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In this study, we investigated the relationship between the cecal intubation time (CIT) and the form and method used for passing through the sigmoid/descending colon junction (SDJ) and the hepatic flexure using an endoscopic position detection unit (UPD), with reference to various factors [age, sex, body mass index (BMI), history of abdominal and pelvic surgery, and diverticulum]. A total of 152 patients underwent colonoscopy with UPD. The mean age was 66.

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Article Synopsis
  • The CLOT-COVID Study analyzed 2894 hospitalized patients with COVID-19, focusing on 1738 patients with mild cases who didn’t need oxygen at admission.
  • Patients were split into two groups: those receiving prophylactic anticoagulation (326 patients) and those who were not (1412 patients).
  • Results showed that those on anticoagulation had higher severity levels during hospitalization and a slightly higher incidence of thrombosis, suggesting that routine use may not be beneficial for all stable patients.
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The necropsy of a 2-day-old Noma horse that died of weakness showed an enlarged cardiac base and a narrow cardiac apex, suggesting cardiac malformation. The excised heart underwent imaging to investigate its luminal structure. On three-dimensional magnetic resonance imaging, the right atrium and right ventricle were discontinuous.

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Article Synopsis
  • The study investigates the impact of eradication therapy on patients with dyspepsia, focusing on short and long-term symptom improvement following treatment.
  • Results showed that about 34.5% of patients experienced symptom relief at 2 months post-eradication, and many maintained improvement up to 12 months.
  • Overall, the findings suggest that patients with dyspepsia associated with a specific infection should consider eradication therapy to reduce their symptoms effectively.
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Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive and/or antiangiogenic agents. As the treatment application for MRONJ is controversial, we aimed to identify the risk factors for poor prognosis and to help determine appropriate management.

Methods: This study included 119 patients.

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Currently, over 500 rare genetic bone disorders are identified. These diseases are often accompanied by dental abnormalities, which are sometimes the first clue for an early diagnosis. However, not many dentists are sufficiently familiar with phenotypic abnormalities and treatment approaches when they encounter patients with rare diseases.

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Background Context: Lumbosacral fusion supplemented with sacropelvic fusion has recently been increasingly employed for correcting spinal deformity and is associated with lower incidence of pseudarthrosis and implant failure. To date, few studies have evaluated anatomical parameters and technical feasibility between different entry points for S2 alar-iliac screws.

Purpose: To compare anatomical parameters and technical feasibility of two entry points for the S2 alar-iliac screw (S2AIS) in a Japanese cohort using three-dimensional (3D) computed tomography (CT).

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This study aimed to investigate the clinical features of arterial thrombosis and venous thromboembolism (VTE) in coronavirus disease 2019 (COVID-19). The CLOT-COVID Study was a retrospective, multicenter cohort study that enrolled 2,894 consecutively hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We compared the clinical features of arterial thrombosis and VTE.

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Introduction: Necrotizing fasciitis as a complication of medication-related osteonecrosis of the jaw (MRONJ), which we named "ONJ-NF", has been sometimes reported. This study aimed to investigate the usefulness of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for predicting ONJ-NF.

Materials And Methods: We included patients with acute MRONJ who required hospitalization at a single institution from April 2013 to June 2022.

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Article Synopsis
  • The study investigates the association between thrombosis and clinical outcomes in hospitalized COVID-19 patients in Japan, using data from the CLOT-COVID study.
  • Patients with thrombosis (55 individuals) experienced significantly higher mortality (23.6% vs. 5.1%) and major bleeding events (23.6% vs. 1.6%) compared to those without thrombosis (2839 individuals).
  • Independent risk factors for thrombosis included being male, having elevated D-dimer levels on admission, and severe COVID-19 status, which could help guide treatment decisions for these patients.
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