Photodynamic Therapy Activity of Phthalocyanine-Silver Nanoparticles on Melanoma Cancer Cells.

The synthesis, characterization and photodynamic therapy activity of a novel metal free phthalocyanine (complex ), with or without silver nanoparticles (AgNPs), are reported. The photodynamic activity of this complex was investigated using metastatic melanoma cancer cell line. In the presence of different concentrations of complex or in combination with silver nanoparticles, the viability of the cells showed a concentration dependent decrease upon irradiation with red light.

Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells.

This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm(2) at 5 J/cm(2) about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively.