Publications by authors named "Ivy Amanor"

Background: To meet the WHO target of eradicating yaws by 2030, highly sensitive and specific diagnostic tools are needed. A multiplex Treponema pallidum-Haemophilus ducreyi loop-mediated isothermal amplification (TPHD-LAMP) test holds promise as a near-patient diagnostic tool for yaws and H ducreyi. We conducted a prospective evaluation in Cameroon, Côte d'Ivoire, Ghana, and the Republic of the Congo to determine the diagnostic accuracy of the TPHD-LAMP test, as well as to assess its acceptability, feasibility, and cost.

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Article Synopsis
  • Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may optimize resource allocation, but extensive data covering multiple endemic countries was previously lacking.
  • Between March 2021 and March 2023, integrated case searches were conducted in Cameroon, Côte d'Ivoire, and Ghana, screening over 61,000 individuals for various skin conditions including yaws and other NTDs.
  • The findings revealed that 18.6% of those screened had skin lesions, with the majority being children; yaws was confirmed in a varying proportion of cases across the three countries, while scabies and fungal infections were the most commonly diagnosed conditions.
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  • - Yaws, caused by the bacterium Treponema pallidum ssp. pertenue, is a major health issue in tropical West Africa and the South Pacific, particularly impacting children in areas lacking hygiene and sanitation.
  • - A study in Ghana, Cameroon, and Côte d'Ivoire found diverse beliefs about yaws transmission among locals, with many attributing it to germs or contaminated water, while some linked it to witchcraft, and a low percentage recognized person-to-person contact as a method of transmission.
  • - Most participants preferred seeking care from hospitals or healthcare professionals if diagnosed with yaws, but there was a significant reliance on traditional healers in Côte d'Ivoire, highlighting the necessity for increased community education and awareness
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  • - A study in the Oti Region of Ghana found that 31.9% of individuals with skin ulcers had cutaneous leishmaniasis (CL), prompting a deeper investigation into other potential causes of these ulcers.
  • - Researchers conducted a community-based study, collecting 101 skin ulcer samples and utilizing PCR tests to identify infections. They discovered 68.3% of samples had co-infections, with high prevalence rates for Leishmania spp., Treponema pallidum sub. Sp. pertenue, and H. ducreyi, but no cases of Mycobacterium ulcerans.
  • - The results highlight the frequent occurrence of multiple skin infections in the area, suggesting a need for a unified research approach and development
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Objectives: The aim was to isolate and identify the species of mycobacteria causing tuberculous-like (TB-like) lesions in cattle in Ghana.

Methods: Between 2019 and 2020, 68 bovine tissue samples with TB-like lesions, identified during post slaughter examination, were obtained from four major abattoirs close to border towns in Ghana. The samples were cultured on Lowenstein-Jensen medium.

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Introduction: Yaws, caused by the bacterium subsp. is a neglected tropical disease targeted for eradication by 2030. Improved diagnostics will be essential to meet this goal.

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Yaws is a skin debilitating disease caused by subspecies with most cases reported in children. World Health Organization (WHO) aims at total eradication of this disease through mass treatment of suspected cases followed by an intensive follow-up program. However, effective diagnosis is pivotal in the successful implementation of this control program.

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