Publications by authors named "Ivonne Kemnitz"
Article Synopsis
- The study investigates how HeLa cells respond to UV-induced damage, revealing that over 90% of cells stay viable up to 6 hours post-irradiation but significantly decline in viability after 12-72 hours.
- The research highlights that the activation of various caspases (key proteins in the cell death process) occurs in a specific sequence after UV exposure, with some being active as early as 1 hour after irradiation.
- Despite the activation of these caspases, the study finds that inhibiting them does not prevent cell death, suggesting that other mechanisms may also play a crucial role in the cell death process post-UV damage.
Article Synopsis
- Hirschsprung's disease (HSCR) is a congenital condition resulting from a defective intestinal neural system, often leading to intestinal obstruction and inflammation, commonly linked to mutations in the RET gene and other related genes.
- A study focusing on the IL11 gene revealed no significant association with HSCR through the analysis of 32 single nucleotide polymorphisms (SNPs) in a Caucasian sample, contrasting previous findings in an Asian population.
- However, a notable association was found with a specific dinucleotide repeat in the IL11 promoter, indicating a potential link between IL11 expression and intestinal inflammation in HSCR patients, particularly those with long-segment HSCR, warranting further research.
Mutations and polymorphisms in the RET gene are a major cause of Hirschsprung disease (HSCR). Theoretically, all true heterozygous patients with a new manifestation of a genetically determined disease must have parents with a genetic mosaicism of some extent. However, no genetic mosaicism has been described for the RET gene in HSCR yet.
View Article and Find Full Text PDF