Publications by authors named "Ivona Matic Jelic"
Congenital muscular dystrophy (CMD) is a group of rare neuromuscular disorders typically characterized by the onset of symptoms at birth or within the first two years of life. CMDs are relatively rare, but extremely severe pathological conditions currently without a safe and effective therapeutic solution. Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is among the most frequent CMDs and it is caused by mutations in the LAMA2 gene that encodes for the α2 chain of laminin-211 (merosin).
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- - The study investigates how bone morphogenetic protein 6 (BMP6) and serotonin (5HT) interact to regulate glucose metabolism, focusing on pancreatic β-cells using rat insulinoma cells and mouse models.
- - Findings indicate that BMP6 and 5HT have opposite effects on insulin secretion, and while BMP6 deletion in mice doesn't lead to diabetes, it causes subtle differences in insulin tolerance.
- - Ultimately, the research concludes that BMP6 does not have a direct impact on glucose metabolism, but its absence may lead to gradual changes in glucose and serotonin metabolism over time, especially as age progresses.
Purpose: We have recently developed an autologous bone graft substitute (ABGS) containing recombinant human bone morphogenetic protein 6 (rhBMP6) in autologous blood coagulum (ABC) that induces new bone formation in vivo. In order to improve biomechanical properties of the implant, compression resistant matrix (CRM) consisting of synthetic ceramics in the form of macroporous cylinders was added to the ABGS and we evaluated the biomechanical properties and the quantity and quality of bone formation following subcutaneous implantation in rats.
Methods: ABGS implants containing rhBMP6 in ABC with cylindrical ceramic blocks were implanted subcutaneously (n = 6 per time point) in the axillary region of Sprague-Dawley rats and removed at specified time points (7, 14, 21, 35, and 50 days).