Publications by authors named "Ivona Kirchbaum"
Mol Neurobiol
January 2025
Article Synopsis
- Perineuronal nets (PNNs) are crucial components of the extracellular matrix that influence synaptic activity and plasticity within interneurons, which are important for brain function and can be affected by disease.
- In a study of 25 human brains, researchers found that different types of PNNs varied in their distribution across cortical layers, with VCAN and NCAN-expressing PNNs predominantly in layers I and VI, while WFA-binding PNNs were more common in layers III-V.
- The team observed significant differences in PNN characteristics based on region and lamination, suggesting that PNNs contribute to the formation of specific microcircuits in the human cortex
