Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity.

New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell driven pathologies are desperately needed. In this perspective, we explore the cytolytic protein perforin as a target for therapeutic intervention. Perforin plays an indispensable role in CTL/NK killing and controls a range of immune pathologies, while being encoded by a single copy gene with no redundancy of function.

Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.

Background: Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad transcriptome changes were measured and compared across four relevant target regions of the rat brain.

Opinion of newly wed Greek couples about the nature and functions of modern family. Similarities and differences with the opinion of Bulgarian couples.

Background: Among the European countries, Greece has exhibited a significant decline in its total fertility rate. Unlike Bulgaria, Greece conducts little in-depth research to study comprehensively the attitudes of newlywed couples toward family planning and reproductive behaviour.

Aim: The present study aimed at exploring the opinion of newly married Greek couples about the nature and functions of modern family and comparing them with those of Bulgarian couples.

Between-birth intervals in newly married Bulgarian families.

Unlabelled: An essential component of the family planning of a newly married couple is determining not only the number of children but also the spacing of births.

Aim: To study the preferences of newly married couples of Bulgarian ancestry from Plovdiv for between-birth intervals and factors that have effect on them.

Methods: The present transversal study was designed to investigate family planning in young families of Bulgarian origin from the town of Plovdiv at the time of submission of documents for state registration of marriage.