Association between Matrix Metallopeptidase 9 Polymorphism and Breast Cancer Risk.

Objective:  Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix components, being involved in the tumor cell invasion and metastasis. Our objective was to evaluate the relationship between the -1562 C/T polymorphism (rs 3918242) and the risk of developing breast cancer.

The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer.

Objective:  Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the gene polymorphism (rs2740574) and the risk of developing breast cancer.

Methods:  In the present case-control study, the frequency of the gene polymorphism was determined in 148 women with breast cancer and in 245 women without the disease.

Breast disease in men in metropolitan São Paulo - Brazil.

Although rare, breast cancer in males represents 1% of all cancer in men, and has shown increasing incidence in 25 years. To analyze age, gender, type of procedure performed and diagnosis of all cases of breast diseases in a public hospital in Sao Paulo, Brazil, with special focus on men. Cross-sectional study of breast surgery in 2010-2014 at Hospital Municipal Universitario de Sao Bernardo do Campo, Brazil.