Abnormal Astrocyte Heterogeneity in the Dentate Gyrus of Rats Prone to Audiogenic Seizures Can Be Corrected by the Nootropic Drug Piracetam.

Accumulating evidence indicates that inherited astrocyte dysfunction can be a primary trigger for epilepsy development; however, the available data are rather limited. In addition, astrocytes are considered as a perspective target for the design of novel and improvement of the existing antiepileptic therapy. Piracetam and related nootropic drugs are widely used in the therapy of various epileptic disorders, but detailed mechanisms of racetams action and, in particular, their effects on glial functions are poorly understood.

Aging of Krushinsky-Molodkina audiogenic rats is accompanied with pronounced neurodegeneration and dysfunction of the glutamatergic system in the hippocampus.

Advancing age strongly correlates with an increased risk of epilepsy development. On the other hand, epilepsy may exacerbate the negative effects of aging making it pathological. In turn, the possible link between aging and epileptogenesis is dysregulation of glutamatergic transmission.

Operating semiconductor quantum processors with hopping spins.

Qubits that can be efficiently controlled are essential for the development of scalable quantum hardware. Although resonant control is used to execute high-fidelity quantum gates, the scalability is challenged by the integration of high-frequency oscillating signals, qubit cross-talk, and heating. Here, we show that by engineering the hopping of spins between quantum dots with a site-dependent spin quantization axis, quantum control can be established with discrete signals.

Spatial memory impairment is associated with decreased dopamine-β-hydroxylase activity in the brains of rats exposed to manganese chloride.

Chronic exposure to manganese compounds leads to accumulation of the manganese in the basal ganglia and hippocampus. High levels of manganese in these structures lead to oxidative stress, neuroinflammation, imbalance of brain neurotransmitters, and hyperactivation of calpains mediating neurotoxicity and causing motor and cognitive impairment. The purpose of this work was to study the effect of excess manganese chloride intake on rats' spatial memory and on dopamine-β-hydroxylase (DβH) activity under conditions of calpain activity suppression.

Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures.

Temporal lobe epilepsy (TLE) development is associated with dysregulation of glutamatergic transmission in the hippocampus; however, detailed molecular mechanisms of pathological changes are still poorly understood. In the present study, we performed the complex analysis of glutamatergic system in the hippocampus of Krushinsky-Molodkina (KM) rats genetically prone to audiogenic seizures (AGS). Daily AGS stimulations (audiogenic kindling) were used to reproduce the dynamics of TLE development.

Postnatal development of the hippocampal GABAergic system in rats genetically prone to audiogenic seizures.

Epileptogenesis can be associated with altered genetic control of the GABAergic system. Here we analyzed Krushinsky-Molodkina (KM) rats genetically prone to audiogenic epilepsy. KM rats express fully formed audiogenic seizures (AGSs) not early, then they reach 3 months.

Studying turbulence in a fluid with background damping.

In this experimental paper, we demonstrate that turbulence can develop in a fluid system with background damping. For that purpose, we analyze dust acoustic waves, self-excited in a fluid complex plasma where the motion of individual microparticles was recorded with a high-speed video camera. We use the Wiener-Khinchin theorem to calculate the kinetic spectrum during different phases of the highly nonlinear periodic wave motion and show that a turbulent cascade develops at the phases of highest particle compression.

Dissipative solitary waves in a two-dimensional complex plasma: Amorphous versus crystalline.

The propagation of a dissipative soliton was experimentally studied in a two-dimensional binary complex plasma. The crystallization was suppressed in the center of the particle suspension where two types of particles were mixed. The motions of individual particles were recorded using video microscopy, and the macroscopic properties of the solitons were measured in the amorphous binary mixture in the center and in the plasma crystal in the periphery.

Dynamics of neurodegeneration in the hippocampus of Krushinsky-Molodkina rats correlates with the progression of limbic seizures.

Audiogenic seizures (AGS) (audiogenic kindling) in genetically selected audiogenic rodents are a reliable model of temporal lobe epilepsy (TLE). Temporal lobe epilepsy is accompanied with neurodegeneration in the hippocampus, but how the cells die is not fully understood. We analyzed the dynamics and mechanisms of cell loss in the hippocampus of audiogenic Krushinsky-Molodkina (KM) rats during the development of TLE.

Effects of Light Spectral Quality on Photosynthetic Activity, Biomass Production, and Carbon Isotope Fractionation in Lettuce, L., Plants.

The optimization of plant-specific LED lighting protocols for indoor plant growing systems needs both basic and applied research. Experiments with lettuce, L., plants using artificial lighting based on narrow-band LEDs were carried out in a controlled environment.

Protective effect of calpain inhibitors against manganese-induced toxicity in rats.

Development of manganism is a major complication of manganese exposure in which neurological dysfunction is linked to accumulation of metal in the brain. Current therapies do not prevent progression of the disease. Therefore, development of effective therapeutic strategies for treatment of manganism is of utmost importance.

Collective self-optimization of communicating active particles.

The quest for how to collectively self-organize in order to maximize the survival chances of the members of a social group requires finding an optimal compromise between maximizing the well-being of an individual and that of the group. Here we develop a minimal model describing active individuals which consume or produce, and respond to a shared resource-such as the oxygen concentration for aerotactic bacteria or the temperature field for penguins-while urging for an optimal resource value. Notably, this model can be approximated by an attraction-repulsion model, but, in general, it features many-body interactions.

Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin.

Some mechanisms of neuronal degeneration in endotoxinemia are already well described, but need to be detailed. In this study, we tested the effect of a single intraperitoneal injection of a LPS sub-septic dose (1 mg/kg of animal weight) on calpain activity in the striatum and hippocampus. We showed, that in the hippocampus the day after LPS administration an increase in production of IL-1β and TNF-α mRNA, followed by elevated mRNA expression and activity of µ- and m-calpains without signs of microglia activation is observed.

Time-dependent inertia of self-propelled particles: The Langevin rocket.

Many self-propelled objects are large enough to exhibit inertial effects but still suffer from environmental fluctuations. The corresponding basic equations of motion are governed by active Langevin dynamics, which involve inertia, friction, and stochastic noise for both the translational and orientational degrees of freedom coupled via the self-propulsion along the particle orientation. In this paper, we generalize the active Langevin model to time-dependent parameters and explicitly discuss the effect of time-dependent inertia for achiral and chiral particles.

Buckling of two-dimensional plasma crystals with nonreciprocal interactions.

Laboratory realizations of two-dimensional (2D) plasma crystals typically involve monodisperse microparticles confined into horizontal monolayers in radio-frequency (rf) plasma sheaths. This gives rise to the so-called plasma wakes beneath the microparticles. The presence of wakes renders the interactions in such systems nonreciprocal, a fact that can lead to a quite different behavior from the one expected for their reciprocal counterparts.

Slow Dynamics in a Quasi-Two-Dimensional Binary Complex Plasma.

Slow dynamics in an amorphous quasi-two-dimensional complex plasma, comprised of microparticles of two different sizes, was studied experimentally. The motion of individual particles was observed using video microscopy, and the self-part of the intermediate scattering function as well as the mean-squared particle displacement was calculated. The long-time structural relaxation reveals the characteristic behavior near the glass transition.

Phase diagram of two-dimensional colloids with Yukawa repulsion and dipolar attraction.

We study the phase diagram of a two-dimensional (2D) system of colloidal particles, interacting via an isotropic potential with a short-ranged Yukawa repulsion and a long-ranged dipolar attraction. Such interactions in 2D colloidal suspensions can be induced by rapidly rotating in-plane magnetic (or electric) fields. Using computer simulations and liquid integral equation theory, we calculate the bulk phase diagram, which contains gas, crystalline, liquid, and supercritical fluid phases.

Dissipative phase transitions in systems with nonreciprocal effective interactions.

The reciprocity of effective interparticle forces can be violated in various open and nonequilibrium systems, in particular, in colloidal suspensions and complex (dusty) plasmas. Here, we obtain a criterion under which a nonreciprocal system can be strictly reduced to a pseudo-Hamiltonian system with a detailed dynamic equilibrium. In particular, the criterion is satisfied for catalytically active colloids interacting via nonreciprocal diffusiophoretic forces.

Full melting of a two-dimensional complex plasma crystal triggered by localized pulsed laser heating.

The full melting of a two-dimensional plasma crystal was induced in a principally stable monolayer by localized laser stimulation. Two distinct behaviors of the crystal after laser stimulation were observed depending on the amount of injected energy: (i) below a well-defined threshold, the laser melted area recrystallized; (ii) above the threshold, it expanded outwards in a similar fashion to mode-coupling instability-induced melting, rapidly destroying the crystalline order of the whole complex plasma monolayer. The reported experimental observations are due to the fluid mode-coupling instability, which can pump energy into the particle monolayer at a rate surpassing the heat transport and damping rates in the energetic localized melted spot, resulting in its further growth.

Flame propagation in two-dimensional solids: Particle-resolved studies with complex plasmas.

Using two-dimensional (2D) complex plasmas as an experimental model system, particle-resolved studies of flame propagation in classical 2D solids are carried out. Combining experiments, theory, and molecular dynamics simulations, we demonstrate that the mode-coupling instability operating in 2D complex plasmas reveals all essential features of combustion, such as an activated heat release, two-zone structure of the self-similar temperature profile ("flame front"), as well as thermal expansion of the medium and temperature saturation behind the front. The presented results are of relevance for various fields ranging from combustion and thermochemistry, to chemical physics and synthesis of materials.

Tunable two-dimensional assembly of colloidal particles in rotating electric fields.

Tunable interparticle interactions in colloidal suspensions are of great interest because of their fundamental and practical significance. In this paper we present a new experimental setup for self-assembly of colloidal particles in two-dimensional systems, where the interactions are controlled by external rotating electric fields. The maximal magnitude of the field in a suspension is 25 V/mm, the field homogeneity is better than 1% over the horizontal distance of 250 μm, and the rotation frequency is in the range of 40 Hz to 30 kHz.

Instabilities in bilayer complex plasmas: Wake-induced mode coupling.

Stability principles for bilayer complex plasmas are studied. To mimic bilayer crystals and identify the main melting mechanism of such structures, a simple binary-chain model is employed. This approach provides adequate representation of the collective effects and accurate description of the interaction nonreciprocity, associated with the wake-mediated interparticle forces.

Wakes in complex plasmas: A self-consistent kinetic theory.

In ground-based experiments with complex (dusty) plasmas, charged microparticles are levitated against gravity by an electric field, which also drives ion flow in the parent gas. Existing analytical approaches to describe the electrostatic interaction between microparticles in such conditions generally ignore the field and ion-neutral collisions, assuming free ion flow with a certain approximation for the ion velocity distribution function (usually a shifted Maxwellian). We provide a comprehensive analysis of our previously proposed self-consistent kinetic theory including the field, ion-neutral collisions, and the corresponding ion velocity distribution.

Emerging activity in bilayered dispersions with wake-mediated interactions.

In a bilayered system of particles with wake-mediated interactions, the action-reaction symmetry for the effective forces between particles of different layers is broken. Under quite general conditions we show that, if the interaction nonreciprocity exceeds a certain threshold, this creates an active dispersion of self-propelled clusters of Brownian particles. The emerging activity promotes unusual melting scenarios and an enormous diffusivity in the dense fluid.

Interpolation method for pair correlations in classical crystals.

Effects of anharmonicity on the pair correlation function of classical crystals are studied. The recently proposed shortest-graph approach using the Gaussian representation of the individual correlation peaks (the peak width is determined by the length of the shortest graph connecting a given pair of particles) is further improved, to account for anharmonic corrections due to finite temperatures and hard-sphere-like interactions. Two major effects are identified, leading to a modification of the correlation peaks at large or short distances: (i) the peaks at large distances, well described by Gaussians, should be calculated from the finite-temperature phonon spectra; (ii) at short distances, the correlation peaks deviate significantly from the Gaussian form due to the lattice discreteness.