Lower expression of tight junction protein 1 gene and increased FOXP3 expression in the small bowel mucosa in coeliac disease and associated type 1 diabetes mellitus.

Background: The role of regulatory T cells expressing FOXP3 in the pathogenesis of coeliac disease (CD) and type 1 diabetes (T1D) has been reported. Recent data have placed special focus on the interplay between the intestinal barrier and immunoregulatory processes. We aimed to determine whether the expression of tight junction protein 1 (TJP1), which reflects small bowel mucosa permeability, is changed in CD and T1D.

Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus.

Objective: To determine whether the expression of FOXP3 is changed in small-bowel mucosa in coeliac disease (CD).

Material And Methods: The study comprised 52 patients (mean age 8.01+/-6.