Synthesis and Psychotropic Properties of Novel Condensed Triazines for Drug Discovery.

The exploration of heterocyclic compounds and their fused analogs, featuring key pharmacophore fragments like pyridine, thiophene, pyrimidine, and triazine rings, is pivotal in medicinal chemistry. These compounds possess a wide array of biological activities, making them an intriguing area of study. The quest for new neurotropic drugs among derivatives of these heterocycles with pharmacophore groups remains a significant research challenge.

Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro[3,2-]pyrrolo[1,2-]pyrimidines, Pyridofuro[3,2-]pyrido[1,2-]pyrimidines and Pyridofuro[3',2':4,5]pyrimido[1,2-]azepines.

Background: Neurotic disturbances, anxiety, neurosis-like disorders, and stress situations are widespread. Benzodiazepine tranquillizers have been found to be among the most effective antianxiety drugs. The pharmacological action of benzodiazepines is due to their interaction with the supra-molecular membrane GABA-a-benzodiazepine receptor complex, linked to the Cl-ionophore.

Derivatives of a new heterocyclic system - pyrano[3,4-][1,2,4]triazolo[4,3-]pyridines: synthesis, docking analysis and neurotropic activity.

8-Hydrazino derivatives of pyrano[3,4-]pyridines and derivatives of the new heterocyclic system 3-thioxopyrano[3,4-][1,2,4]triazolo[4,3-]pyridines on the basis of methanesulfonates of pyrano[3,4-]pyridinium were synthesized by optimization of a previously used method. Derivatives of alkylsulfonyl pyrano[3,4-][1,2,4]triazolo[4,3-]pyridines were also synthesized. All compounds were evaluated for their neurotropic activity.