Laboratory characterization of leukemic cell procoagulants.

Background: In acute myeloid leukemias, there is an increased chance to develop thrombotic disorders. We hypothesized that in addition to leukemic promyelocytes, monocytic leukemia cells may also have a higher procoagulant activity.

Methods: Fibrin formation was assessed by a one-stage clotting assay using a magnetic coagulometer.