Complications of oxidised regenerated cellulose at Caesarean section: A report of two cases.

Two patients underwent surgical deliveries within four months of one another at a single maternity unit. Both patients had complications of infection-like symptoms such as offensive vaginal discharge and pyrexia, months following their caesarean sections resulting in further surgery. The incidents were thought to be secondary to woven oxidised regenerated cellulose (ORC) use.

Challenges in manufacturing adenoviral vectors for global vaccine product deployment.

Abstract Once adenovirus vector-based vaccines are licensed for the prevention of important infectious diseases, manufacturing processes capable of reliably delivering large numbers of vaccine doses will be required. The highest burden of disease for many infectious pathogens under investigation occurs in resource-poor settings. Therefore, the price per dose will be an important determinant of success.

Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus.

This paper reports a novel use of cluster analysis for the identification of intermediary metabolites that are produced at rates closely correlated with those of antibiotic biosynthesis. This information was used to devise culture feeds resulting in enhanced production of clavulanic acid, an antibiotic of current worldwide commercial interest. The feeding strategies apparently alleviated a rate-limiting supply of the C3 precursor of clavulanic acid.

Respiratory responses to repeated prolonged exposure to 0.12 ppm ozone.

Repeated exposure to high concentrations of ozone results first in augmentation (typically on the second day) and then attenuation of pulmonary response in humans. To determine the effects of repeated prolonged low-concentration ozone exposure, we exposed 17 healthy nonsmoking male subjects to 0.12 ppm ozone for 6.

Respiratory response of humans exposed to low levels of ozone for 6.6 hours.

Recent evidence suggests that prolonged exposures of exercising men to 0.08 ppm ozone (O3) result in significant decrements in lung function, induction of respiratory symptoms, and increases in nonspecific airway reactivity. The purpose of this study was to confirm or refute these findings by exposing 38 healthy young men to 0.

Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm.

The magnitudes of pulmonary responses we previously observed (1) following 6.6-h exposures to 0.12 ppm ozone (O3) suggested that responses would also occur with similar exposures at lower O3 concentrations.

Pulmonary function, airway responsiveness, and respiratory symptoms in asthmatics following exercise in NO2.

Two experiments were conducted to determine respiratory responses of persons with asthma performing intermittent moderate exercise while exposed to low concentrations of NO2. In the first, preliminary experiment, 13 male subjects, aged 19-35, with mild asthma were exposed on separate days in a chamber (natural breathing, 20 degrees C, 40% RH) to 0.30 ppm NO2 and to a control or "clean air" exposure (0.

The relationship between exposure duration and sulfur dioxide-induced bronchoconstriction in asthmatic subjects.

The purpose of this study was to determine the shortest duration of exposure to 1.0 ppm sulfur dioxide (SO2) sufficient to induce bronchoconstriction significantly greater than that observed with exposure to clean air (CA) in exercising SO2-sensitive asthmatics. Asymptomatic, nonmedicated, male asthmatics (n = 12) with airway hyperresponsiveness to both methacholine and SO2 were exposed in a chamber (20 degrees C, 40% relative humidity) for 0.

CONTINUING STUDIES ON THE SOUTH AMHERST DROSOPHILA MELANOGASTER NATURAL POPULATION DURING THE 1970'S AND 1980'S.

Continuing investigations on the South Amherst Drosophila melanogaster natural population following the significant decline and recovery of lethal (le) and semilethal (sle) frequencies in the late 1960's (Ives, 1970) show that the population has been remarkably stable although it contains MR (male recombination) and/or P DNA elements (Kidwell et al., 1977a; Green, 1980). A 13-year study affirms that the lethals present are nonrandomly distributed along the second chromosome and deficient on the right; they differ significantly in distribution from spontaneous (Ives, 1973) and δ-induced lethals (Minamori and Ito, 1971).

The existence of LSP-1 beta S in Drosophila melanogaster natural populations in two northern states.

LSP-1 beta S is present in Michigan and Massachusetts Drosophila melanogaster natural populations. Its frequency, 10%, is significantly higher in an East Jordan, Mich. (latitude, 45.

The armadillo infundibulum: correlative histochemistry, scanning and transmission electron microscopy of the ventricular surface.

The ependymal and supraependymal cells of the armadillo infundibulum (INF) were investigated by correlative histochemistry, scanning and transmission electron microscopy. Eighteen armadillos (8 adult females, 6 adult males, 2 immature females and 2 immature males) were examined. The following supraependymal elements were observed: (a) individual pleiomorphic cells made up of neurons, macrophages, and astrocytic-glial cells; (b) numerous spherical blebs of various sizes occurring singly or in clusters; (c) axons, traversing the surface alone or in association with macrophages and other SEC; (d) multicellular clusters containing SEC, macrophages, axons and other cell types.

Transventricular blood vessels in the third ventricle of the armadillo brain.

Transventricular filaments were observed with scanning electron microscopy on the dorsolateral wall of the infundibular recess of the third ventricle of the armadillo brain. Two to seven transventricular filaments per animal were present in 6 of 18 animals. There were two types of transventricular filaments, ciliated and bare.

A histochemical and ultrastructural study of lipofuscin accumulation in thyroid follicular cells of aging domestic cats.

Enzyme activity and fine structure of thyroid follicular cells were investigated in domestic cats at ages: 2 and 8 months, and 1, 3, 5 and 8 years. The following major changes in the follicular cells with advancing age were observed: with histochemistry--an increase in acid phosphatase and beta-glucuronidase activities confined to numerous granules (vesicles); with electron microscopy -- an increase in colloid vesicles, the appearance and increase in size and number of lipofuscin vesicles, and the increase in number of follicular cells containing numerous colloid or lipofuscin vesicles. It is our opinion that the numerous enzymatically active granules of the older groups, observed with histochemistry, are synonymous with the lipofuscin vesicles and many of the colloid vesicles observed with electron microscopy.