Publications by authors named "Ivelise Dimbarre Lao Guimaraes"

The mechanism of chemotherapeutic action of Ru-based drugs involves plasma membrane disruption and valuable insights into this process may be gained using cell membrane models. The interactions of a series of cytotoxic η-p-cymene ruthenium(II) complexes, [Ru(η-p-cymene)P(3,5-C(CH)-CH)Cl] (1), [Ru(η-p-cymene)P(3,5-CH-CH)Cl] (2), [Ru(η-p-cymene)P(4-CHO-3,5-CH-CH)Cl] (3), and [Ru(η-p-cymene)P(4-CHO-CH)Cl] (4), were examined using Langmuir monolayers as simplified healthy and cancerous outer leaflet plasma membrane models. The cancerous membrane (CM1 and CM2) models contained either 40 % 1,2- dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 30 % cholesterol (Chol), 20 % 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), and 10 % 1,2-dipalmitoyl-sn-glycero-3-phospho-l-serine (DPPS).

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Polycyclic aromatic hydrocarbons (PAHs), the main component of petroleum, are a concern due to their environmental persistence, long-range transport, and potential toxic effects on animal, human health, and the environment. PAHs are considered persistent compounds and can be bioaccumulated in sediments and aquatic biota. Determining PAHs in animals and environmental samples consists of three steps: extraction, clean-up or purification, and analytical determination.

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Background: Polycyclic aromatic hydrocarbons (PAHs) are persistent pollutants routinely detected in aquatic ecosystems. It is, therefore, necessary to assess the link between deleterious marine biota PAH effects, especially in commercialized and consumed animals, environmental health status, and potential human health risks originating from the consumption of contaminated seafood products. Thus, this review seeks to verify the relationships of ecotoxicological studies in determining effect and safety concentrations on animals routinely consumed by humans.

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