Publications by authors named "Ivayla Dincheva"

Article Synopsis
  • There is growing interest in natural antioxidants, particularly phenolics, for preventing diseases linked to oxidative stress due to their effectiveness and lower side effects compared to synthetic options.
  • Researchers analyzed Meadowsweet, a traditional herb known for treating various ailments, using HPLC and bioassays to evaluate its antioxidant, antiproliferative, and DNA-protective properties.
  • The study found that Meadowsweet's dry tincture contains 12 key phenolics and demonstrated significant protective effects against oxidative DNA damage and anti-cancer properties against HepG2 cells, highlighting its potential in disease prevention.
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Essential oils (EOs) extracted from aromatic and medicinal plants have the potential to inhibit the growth of various pathogens and, thus, be useful in the control of dangerous diseases. The application of environmentally friendly approaches to protect agricultural and forestry ecosystems from invasive and hazardous species has become more significant in last decades. Therefore, the identification and characterization of essential oils with a strong inhibitory activity against aggressive and widespread pathogens are of key importance in plant protection research.

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Article Synopsis
  • There is currently no existing research on the L. plant species found in Bulgaria, prompting this study to analyze its leaves and pulp for metabolic, elemental, and bioactive properties.
  • The pulp was rich in fructose and amino acids, while both leaves and pulp contained various essential fatty acids and minerals, with potassium and magnesium being most abundant.
  • The study found that leaf extracts demonstrated superior antioxidant and anti-inflammatory effects, as well as notable antibacterial activity, suggesting potential uses in nutritional and cosmetic products.
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The present study aims to elucidate the metabolomic profile of grown in a bioreactor in Bulgaria. The results show that has a high content of mannose, 137.02 mg g, and vitamin A (retinol)-10.

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The aims of this study were to (1) establish the intrapopulation and seasonal variation of Juniperus excelsа essential oil (EO); (2) compare the J. excelsa concrete and resinoid composition with its EO composition; and (3) investigate the potential herbicidal activity of J. excelsa EO against seeds of Papaver rhoeas L.

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Pentacyclic triterpenoids are a diverse subclass of naturally occurring terpenes with various biological activities and applications. These compounds are broadly distributed in natural plant resources, but their low abundance and the slow growth cycle of plants pose challenges to their extraction and production. The biosynthesis of pentacyclic triterpenoids occurs through two main pathways, the mevalonic acid (MVA) pathway and the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, which involve several enzymes and modifications.

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Introduction: Centranthus kellereri is a Bulgarian endemic plant species, found only in two locations in the world: The Balkans Mountains (Stara Planina), above the town of Vratsa, and The Pirin Mountains, above the town of Bansko, Bulgaria. Being endemic and endangered species precluded any significant research on it. The hypothesis of this study was that the populations of C.

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Augmented knowledge of plant responses upon application of stress could help improve our understanding of plant tolerance under abiotic stress conditions. Histone acetylation plays an important role in gene expression regulation during plant growth and development and in the response of plants to abiotic stress. The current study examines the level of transcripts and free metabolite content in transgenic plants expressing a gene encoding histone acetyltransferase from () after its heterologous expression.

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(SE) fruits are used for immune stimulation and amelioration of gastrointestinal inflammatory conditions. Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potential of SE fruit infusion intake in healthy humans.

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The genus , belonging to the family Lamiaceae, includes about 300 species, most of which are used in folk medicine due to their pronounced biological properties. The aim of the present study was to evaluate the agrobiological characteristics of () Grossh. and () L.

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species and especially L. are well known for their therapeutic applications. The present study assessed the essential oil (EO) composition, and antifungal and aphid suppression activity of seven Bulgarian species.

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Plant bioactive compounds are essential for human health due to their multiple biological effects, such as antioxidant, anticarcinogenic, antiallergenic, anti-inflammatory, antimutagenic, and antimicrobial activities, which can have beneficial effects on various noncommunicable diseases, such as autoimmune, inflammatory, cardiovascular, cancer, metabolic, and neurodegenerative diseases [...

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Sustainability, becoming essential for food processing and technology, sets goals for the characterization of resources considered as food waste. In this work, information about the GC-MS metabolites of peach peels was provided as a tool that can shed more light on the studied biological activities. In addition, distribution patterns and contribution of the chemical profile and free and bound phenolic compounds as antioxidant, antimicrobial, and enzymatic clusters in peach peels of different varieties of Bulgarian origin were studied.

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A fruit's aroma profile, composed of a complex mixture of volatile organic compounds, is among the core attributes related to the overall taste and consumer preference. L. is a preferred summer fruit with a distinct, favorable olfactory characteristic.

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L. (black chokeberry), belonging to the Rosaceae family, contains high amounts of polyphenolics and therefore exhibits one of the highest antioxidant and anti-inflammatory activities among berry fruits. Chokeberries are used in the food industry for juice, nectar, and wine production and as colorants.

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Potatoes ( L.) are the fourth most economically important crop in the world. They have a short period of vegetation and are an excellent source of carbohydrates, amino acids, vitamins, organic acids, minerals and phenolics as antioxidant substances.

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Phytogenics are plant extract additives used for their bioactive properties. The objective of this study was to assess the effect of plant extracts, wheat grass juice (WGJ) and barley grass juices (BGJ) addition to fish diet on growth and meat quality of common carp. Fish (51 ± 33 g initial weight) were fed for four weeks with three plant-based diets: (1) control feed (Con), (2) control feed supplemented with 2% WGJ (Con+WGJ), and (3) control feed supplemented with 2% BGJ (Con+BGJ).

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This study compared the essential oils (EO) composition of (Bulgarian populations) with that of the cultivated species . The EO composition of and were analyzed via gas chromatography. In general, 75 components were identified in EO and 79 in EO.

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The volatile compounds of eight peach varieties ( L.)-"Filina", "Gergana", "Ufo-4", "July lady", "Laskava", "Flat Queen", "Evmolpiya", and "Morsiani 90"-growing in Bulgaria were analyzed for the first time. Gas chromatography-mass spectrometry (GC-MS) analysis and the HS-SPME technique revealed the presence of 65 volatile compounds; the main identified components were aldehydes, esters, and fatty acids.

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L. (SE) fruits are used for their immunostimulation, hematopoietic and antiviral potential. Recently, we focused on analyzing the mechanism underlying SE fruit aqueous extract's (FAE) immunomodulation and anti-inflammatory activities, with attention to its endoplasmic reticulum (ER) stress-reducing potential.

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The objective of this study was to assess the biological activity of essential oils (EOs) of four species obtained via two different distillation methods and their potential as biopesticides. The studied factors were juniper species ( L., L.

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The purpose of this study was to perform phytochemical analysis of tea from Sambucus ebulus fruits concerning hydroxycinnamic acids, flavonol glucosides, stilbenes and proanthocyanidin mono-, di- and trimers content. In total, 33 compounds were identified and quantified using UPLC-DAD-ESI/MS/MS system and the results are presented in mg/g dry weight (DW). Among analyzed hydroxycinnamic acids, 5-Caffeoylquinic acid (114.

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The inhibition of certain digestive enzymes by target food matrices represents a new approach in the treatment of socially significant diseases. Proving the ability of fruits to inhibit such enzymes can support the inclusion of specific varieties in the daily diets of patients with diabetes, obesity, Alzheimer's disease, etc., providing them with much more than just valuable micro- and macromolecules.

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M. Bieb and L. contain essential oil (EO), while also contains podophyllotoxin, which is used as a precursor for anti-cancer drugs.

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The F-box domain is a conserved structural protein motif that most frequently interacts with the SKP1 protein, the core of the SCFs (SKP1-CULLIN-F-box protein ligase) E3 ubiquitin protein ligases. As part of the SCF complexes, the various F-box proteins recruit substrates for degradation through ubiquitination. In this study, we functionally characterized an F-box gene (MtF-box) identified earlier in a population of Tnt1 retrotransposon-tagged mutants of Medicago truncatula and its Arabidopsis thaliana homolog (AtF-box) using gain- and loss-of-function plants.

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