[Cholinesterase activity and the rate of the maturation of the sensorimotor reflexes in the progeny of white rats administered carbophos during pregnancy].

Female mongrel albino rats were administered orally carbophos in a dose of 10 mg/kg (1/100 of LD50) on the 11th, 13th, 15th and 17th days of pregnancy. The antenatal administration of carbophos was shown to produce combined disturbances of the postnatal development of the mongrel albino rats manifesting themselves in changes of the maturation of sensomotor reflexes, cholinesterase activity, increased addiction both to carbophos and ethanol.

[The occurrence of addiction to karbofos in the progeny of rats administered it during pregnancy].

Female albino rats weighing 200-250 g received intragastrically carbophos solution in doses of 100, 10 and 5 mg/kg corresponding to 1/10, 1/100 and 1/200 of LD50 on the 11th, 13th, 15th and 17th days of pregnancy. Two-month old young rats were tested to determine addiction to carbophos. It was found that the body weights of the offspring of the rats given carbophos in doses of 10 and 5 mg/kg were musch less than in control.