Multiclass Level-Set Segmentation of Rust and Coating Damages in Images of Metal Structures.

This paper describes the combined detection of coating and rust damages on painted metal structures through the multiclass image segmentation technique. Our prior works were focused solely on the localization of rust damages and rust segmentation under different ambient conditions (different lighting conditions, presence of shadows, low background/object color contrast). This paper method proposes three types of damages: coating crack, coating flaking, and rust damage.

Effect of combined treatment with aspirin and dipyridamole on oxidative homeostasis in mouse serum.

Using the method of peroxidative luminol-dependent chemiluminescence we showed that combined treatment with aspirin in low dose and dipyridamole corrects imbalance in oxidative homeostasis in mouse serum. This state resulted from a sharp increase in prooxidant processes after platelet disaggregation with normal dose of aspirin or dose-dependent inhibition of free radical processes with dipyridamole.

Effect of imbalance in plasma oxidant homeostasis on the choice of stromal differentiation of polypotent bone marrow stem cells in mice receiving estrone injection.

The choice of stromal differentiation by polypotent stem cells was studied by morphological and chemiluminescent methods. The differentiation pathway is selected on day 7 after heterotopic bone marrow transplantation and injection of estrone. The imbalance in plasma oxidant homeostasis in mice on day 7 after estrone injection is associated with drastic intensification of free-radical oxidation and blockade of antioxidant activity.

Effect of disturbed plasma oxidant homeostasis on hemopoietic differentiation of polypotent bone marrow stem cells in mice treated with dipyridamole.

The choice of hemopoietic differentiation by polypotent bone marrow stem cells was studied by morphological and chemiluminescent methods. This choice occurred on day 7 after heterotopic bone marrow transplantation and dipyridamole administration, under the effect of oxidative homeostasis imbalance in the plasma. Dipyridamole increased total antioxidant activity and 10-fold reduced the intensity of free radical oxidation.

Free radical oxidation and antioxidant activity in blood plasma and myocardium during long-term dipyridamole treatment.

Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. Dipyridamole-induced platelet disaggregation was accompanied by an increase in platelet count.

[A clinical and experimental validation of the use of Stimuloss in patients with chronic generalized periodontitis].

The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug.

[The regulation of bone marrow hematopoiesis in splenectomy and splenic autotransplantation in mice].

The method of heterotopic transplantation of the bone marrow was used to study the influence of splenectomy and autotransplantation of the spleen onto the hemopoietic and osteogenic tissues of the bone marrow in mice. After splenectomy at early stages of the formation of the heterotopic hemopoiesis focus the amount of myelokaryocytes increased while in the stationary bone marrow population (the femur bone) their amount dropped by the same time. Autotransplantation of the spleen made the amount of myelokaryocytes equal to the level of control, but did not eliminate the effect of decrease of the mass of osteogenic tissue in the heterotopic hemopoiesis focus arising after splenectomy, which might be related with the influence of splenectomy on the stem osteogenic cells-precursors of the bone marrow.

[The action of dipyridamole on megakaryocytopoiesis in regenerating and stationary bone marrow cell populations].

The effect of dipyridamole on megakaryocytopoiesis in regenerating and stationary populations of mouse bone marrow cells has been studied by heterotopic transplantation of the bone marrow using histological, electron microscopic and biochemical techniques. It is shown that drug administration induced destruction of megakaryocytes. In megakaryocytic cytoplasm giant lipid granules were found whose growth and number increase resulted in megakaryocytes kill.

[The effect of hydroxylapatite on the experimental healing of the tooth socket].

Synthetic hydroxylapatite, a drug made in this country, enhanced reparative osteogenesis if introduced in the dental well of a white rat. The regenerate represented solid bone structure in 4 months after tooth removal.

[Compensation-adaptation reactions of hemopoiesis-inducing microenvironment of bone marrow in stress].

The time course of compensation-adaptation reactions of bone marrow hemopoiesis-inducing microenvironment (HIM) was studied in F1 (CBA x C57BL/6) mice subjected to 10-hour immobilization. The number of macrophage and fibroblastoid colony-forming units, committed and stem precursor stroma cells responsible for HIM transport was shown to increase in the hemopoietic tissue during adaptation syndrome. HIM activation in stress was found to be macrophage- and lymphocyte-dependent process.

[Effect of dipyridamole on the interrelations of the stromal and hematopoietic tissues of the bone marrow in experimental studies].

By means of heterotopic transplantation of the bone marrow interrelations of the stromal and hemopoietic tissues of the mice bone marrow have been studied at administration of dipiridamol. Effect of the drug to the hemopoiesis is realized via stem stromal cells of the bone marrow. Under the influence of dipiridamol a focus of heterotopic hemopoiesis the osteogenic component in it is present only in 30% of cases in comparison with the control.

[Role of stromal microenvironment in the regulation of bone marrow hemopoiesis after curantyl administration].

Role of the stromal microenvironment in regulation of bone marrow hemopoiesis at the administration of the thrombocyte disaggregant curantyl was studied by the method of heterotopic transplantation of the mice bone marrow. It is shown that the action of curantyl on hemopoiesis is realised through the stem stromal cells of the bone marrow. It is noted that the inhibitory action of the preparation on proliferation of osteogenic precursor-cells is followed by activation of bone resorption processes in regenerating ectopic hemopoietic organ.

[Interrelations between hemopoietic microenvironment, osteogenesis and hemopoiesis under the effects of estrone].

The effect of estrone injections on heterotopic marrow organ formation and femoral hemopoiesis and osteogenesis was studied in C57B1 X CBAF1 mice. Estrone injections resulted in decreased hemopoiesis in femoral marrow, its fibrosis and reduced cellularity of heterotopic organ. Any correlations between osteogenic and hematopoietic tissue were not revealed.

[The role of the thymus in regulating the stromal cells responsible for the transfer of the hemopoiesis-inducing microenvironment in stress].

The role of thymus in the regulation of stromal elements, responsible for haemopoiesis inducing microsurrounding transfer of animals, subjected to 10-hours immobilization, was studied. The development of bone marrow hyperplasia and stimulation of functional activity of stromal cells, responsible for haemopoiesis inducing microsurrounding transfer, were shown to be thymus dependent processes during stress.

[Interrelation of the osteogenic and hemopoietic tissues of the bone marrow during the development of estrogenic myelofibrosis].

By means of estrogenic myelofibrosis, using the method of heterotopic transplantation of the bone marrow, interrelations of osteogenic and hemopoietic tissues have been studied. Under estrone effect disorders in stromal microenvironment take place at the level of stem osteogenic cells of the bone marrow. Deficiency in cells of monocytic-macrophagal line, inhibiting proliferation of the bone marrow connective tissue cells, contributes to development of myelofibrosis.

[The role of glycosaminoglycans in regulation of medullary hematopoiesis in stress].

The role of the constituents of hematopoiesis inducing bone marrow microenvironment in myelopoiesis regulation was studied. It was found that during the development of the general adaptation syndrome the functional activity of stroma cells and granulomonocytopoiesis precursor cells intensifies and the content of acid glycosaminoglycans in the bone marrow increases. It is shown that acid glycosaminoglycans produce an effect on the myelokaryocytes in intimate interrelationship with the prostaglandin system, changing the level of intracellular calcium and cAMP in the hematopoietic cells.

[Effect of a deficiency in the mononuclear phagocyte system and the administration of yeast polysaccharide on the development of a heterotopic source of hematopoiesis].

Mononuclear phagocyte system (MPS) deficiency was induced by repeated peritoneal lavage in (C57Bl x CBA) F1 mice. The animals were then used as donors or recipients in heterotopic bone marrow transplantation. Yeast polysaccharide (YP) produced by Cryptococcus luteolus strain 228 was injected weekly (25 mg/kg) during 30 days after bone marrow transplantation under the kidney capsule.

[Role of the stromal microenvironment in regulating bone marrow hemopoiesis under stress].

The role of stromal microenvironment in bone marrow hemopoiesis during stress has been studied. The stimulation of functional activity of stromal cells, responsible for the transfer of hemopoiesis-inducing microenvironment has been found. The time required for the development of microenvironment coincide with the moment of T-lymphocyte appearance in the bone marrow.

[Formation of a heterotopic hemopoiesis focus from the administration of a cryptococcal heteropolysaccharide to bone marrow donors and recipients].

The effect of Cryptococcus luteolus (strain 228) heteropolysaccharide on heterotopic bone marrow organ formation was studied. Heteropolysaccharide (Hp) injections were initiated on the next day after bone marrow transplantation and were performed weekly for 30 days. This resulted in the increase in both the cellularity and the weight of the ossicle.

[Effect of estrone on formation of the focus of heterotopic hematopoiesis].

The effect of estrone injections on the heterotopic bone marrow organ formation was studied in (C57Bl X CBA)F1 mice by bone marrow shaft transplantation under the kidney capsule. Estrone injections resulted in femur marrow fibrosis, the increase in the weight of femur and heterotopic organ ossicle, drastic reduction in heterotopic organ cellularity. Depression of hemopoiesis in ectopic organ cannot be attributed to mechanical displacement of hemopoietic cells because a newly formed bone cavity under the kidney capsule was not closed.