Publications by authors named "Ivars Karpics"
Article Synopsis
- COVID-19, caused by SARS-CoV-2, is a severe global health crisis with no direct treatment available.
- Researchers conducted a high-throughput x-ray crystallography screen on repurposed drug libraries targeting the virus's main protease, which is crucial for its replication.
- They identified 37 compounds that bind to the protease and found two promising allosteric binding sites, with several compounds showing antiviral activity without toxicity in further tests.
Article Synopsis
- MXCuBE2 is an upgraded version of the original MXCuBE beamline control software, enhancing user experience with improved graphical user interface (GUI) and expanded functionalities.
- It introduces a flexible abstraction layer for easy integration of various macromolecular crystallography (MX) hardware, including detectors and sample changers.
- The software works seamlessly with the ISPyB Laboratory Information Management System, allowing for efficient data collection and management within a collaborative framework among several European synchrotrons.
The macromolecular crystallography P13 beamline is part of the European Molecular Biology Laboratory Integrated Facility for Structural Biology at PETRA III (DESY, Hamburg, Germany) and has been in user operation since mid-2013. P13 is tunable across the energy range from 4 to 17.5 keV to support crystallographic data acquisition exploiting a wide range of elemental absorption edges for experimental phase determination.
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