[Problems of diagnosis and prevention of occupational malignancies].

The authors presented statistics on quantity of registered occupational malignancies in Russian Federation and some foreign countries, analyzed causes of difficult diagnosis of occupational malignancies, suggested ways to improve the situation.

[Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients from Yakutia].

DNA polymorphism is an important component of the interindividual variation in reactions of patients to the same drugs. In this work, evaluation of the association between polymorphisms in 106 genes involved in key processes of cellular activity (xenobiotic metabolism, DNA repair, the cell cycle, and apoptosis), and outcomes in a cohort of Yakut ovarian cancer patients receiving cisplatin-based chemotherapy was carried out. The polymorphism in the CDKN1B gene (rs34330) was found to be associated with complete tumor response and progression-free survival.

[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].

The CYP2E1 gene polymorphism has been studied in Yakut women with ovarian cancer and without cancer. The two groups have been found to substantially differ in the frequency of the CYP2E1* 1D allele (with a 96-bp insertion in the promoter region of the gene): it is more frequent in healthy women (16.3 versus 7.

Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins.

Aim: There is a substantial difference between Asians and Caucasians in their reaction to platinum drugs. To determine whether population-related genomics contribute to differences in patient outcomes, pharmacogenomic relevance of polymorphisms in some genes, the protein activities of which may affect aspects of cisplatin metabolism, were evaluated.

Patients & Methods: Nineteen polymorphisms in ten genes were tested for correlations with the efficacy and toxicity of a cisplatin-cyclophosphamide regimen in Yakut and Russian patients with ovarian cancer.

[Physician continuing education on occupational diseases as an integral part of the national project "Health Promotion"].

The author's concepts are evaluated positively and additional organizational and practical recommendations are suggested to increase quality of doctors' postgraduate training in occupational therapy.

[Scientific activities of Occupational Medicine Department with St Petersburg Medical Academy for Postgraduate Education].

The article deals with materials devoted to 80th anniversary of scientific activities of Occupational Medicine Department with St Petersburg Medical Academy for Postgraduate Education. Theoretic, scientifical and practical data on achievements on various stages of longstanding history are presented. The authors prove the research carried by the Department to be important and promising for occupational hygiene and industrial medicine.

[Flow cytometric DNA analysis and neoadjuvant chemotherapy of cervix cancer (stage IB2-IIIB)].

The purpose of the present study is to determine the predictive role of the data of flowcytometric DNA-analysis--aneuploidity DNA-index, proliferative index in patients with squamous cervical cancer who was given chemotherapy as a initial treatment. The data of 12 patients in stage IB2-IIIB, who were divided into two groups according to the second-line treatment--surgery of definitive radiotherapy, were analysed. These data were correlated with the respond of the tumor to neoadjuvant chemotherapy (clinical and histopathological) as well as other factors such as stage, size of tumor lesion, grading disease free survival.

[Results of epidemiological research in occupational morbidity].

The authors present materials on real prevalence of occupational diseases, calculate the diseases' share per economically active population, demonstrate thorough analysis of occupational morbidity in major industrial city, prove positive role of Occupational Pathology Center.

[Indicators of occupational morbidity in relation to economically active population].

The authors suggest using 10,000 economically active inhabitants instead of 10,000 working inhabitants for calculation of occupational morbidity parameters, as the first term is wider than the second one excessively used now. The parameter suggested is more objective, provides a universal approach to evaluation of occupational morbidity level and, therefore, enables to compare the parameters for various states.