A multi-device and multi-operator dataset from mobile network coverage on Android devices.

The demand for mobile coverage with adequate signal quality has triggered criticism due to the maturity of the Internet's diffusion in today's society. However, with the deployment of 5G networks, even 5G NSA by 4G LTE, the complexity of the operating environment of mobile networks has increased. To evaluate the behavior of mobile networks in terms of signal quality and other important metrics for mobile telephony, we developed a dataset consisting of 33 radio parameters that can collect up to 736,974 records generated daily by smartphones and tablets.

Nucleotide modifications in messenger RNA and their role in development and disease.

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

Adolescent patient with bilateral crossbite treated with surgically assisted rapid maxillary expansion: a case report evaluated by the 3d laser scanner, and using FESA method.

Our purpose in this case report is to present an orthodontic treatment obtained and the results achieved in 17-year-old white female patient with Angle Class II malocclusion and bilateral posterior crossbite. Patient was treated with bonded acrylic Hyrax appliance and surgically assisted rapid maxillary expansion (SARME). The multiloop system 0.

[Our and foreign experience in surgical staging of early ovarian cancer].

Aim: The aim of our research work was to assess the influence and effect of pelvic and paraaortic lymph node excision as well as peritoneal biopsies as part of the surgical staging in early ovarian cancer. We tried to evaluate the free of disease survival rate and the overall survival rate in patients with early ovarian cancer treated surgically without adjuvant chemotherapy

Material And Methods: We assessed 460 patients operated for early ovarian cancer without adjuvant chemotherapy. The researched period included 1995-2011.

[Modern tendencies in treatment of endometrial cancer].

Aim: We tried to summarise our and foreign experience in the modern treatment of endometrial cancer.

Material And Methods: We evaluated for 10 years period 400 patients treated surgically, as well as treated with postoperative radiotherapy. We tried to give the allgorhythm for treatment of this kind of cancer.

[Preoperative and intraoperative evaluation of myometrial invasion in endometrial cancer by progesterone-challenge test, CT scan, magnetic resonance imaging, PET scan and intraoperative visual evaluation and Frozen section].

Aim: Our aim was to compare the diagnostic value and accuracy of progesterone-challenge test combined with TVS, CT scan, MRI, Pet scan and Visual and histologic evaluation (Frozen section) for assessment of Myometrial invasion of the endometrial cancer.

Methods: Our research work includes 300 patients with endometrial cancer for the period of 1999-2009. All of them were found by Progesterone challenge test combined with TVS, Collor-doppler sonography, who additionally were examined by CT MRI and Pet scan.

[Modern tendencies in HRT of patients treated for endometrial cancer].

Aim: Our aim was to evaluate the effect of HRT on endometrial cancer patients

Material And Methods: We applied HRT in 250 patients-locally (cream) and in 300 patients in other routes and doses-tablet form, estradermal form, implant form. The research and the follow up were done for 10 years period.

Results: When we applied unopposed estrogen (0.

[Our experience in the surgical treatment of advanced endometrial cancers].

Aim: Our aim was to summarise our experience in the surgical treatment of advanced endometrial cancers for 20 years period.

Material And Methods: The patients were treated surgically by extrafascial hysterectomy, radical hysterectomy with pelvic and paraaortal lymph node dissection, by pelvic exenteration and by cytoreductive surgery (350 patients). The radical hysterectomy was applied in patients with stage II endometrial cancer.

Optical plastic refractive measurements in the visible and the near-infrared regions.

Some new refractometric results are obtained in the visible and the near-infrared spectral regions. The main optical plastics are analyzed: poly(methyl methacrylate), polystyrene, polycarbonate, and styrene acrylonitrile. New materials, such as methyl methacrylate styrene copolmer, CTE-Richardson, Zeonex, Optorez, and Bayer are examined.

[Clinical application of Bionect (Hyaluronic Acid Sodium Salt) in wound care by cesarean section and episiotomy].

Unlabelled: Hyaluronic acid is an important component of extracellular matrix and plays crucial role in wound healing by stimulation of neutrophil migration, fibroblasts proliferation and neoangiogenesis.

Objective: To study the efficacy of topical application of of Bionect (Hialuronic Acid Sodium Salt) in wound care in cases of episiotomy and cesarean section surgical wounds.

Materials And Methods: 27 patients, delivered by cesarean section and 20 patients with vaginal delivery with episiotomy were included in a prospective study.

Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks.

The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the "pH/temperature induced" phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.

Effects of 4-(4-bromophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride on acute gastric lesions, acid secretion in rats and on some hemodynamic parameters in cats.

The effectiveness of 4-(4-bromophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (AN12) on acute ulcer models and gastric acid secretion in rats was compared with the action of the histamine H2-receptor antagonist roxatidine (R). AN12 or R given orally, produced significant, dose-dependent decreases in stress- and indomethacin-induced ulcers. The ED50 value of AN12 and R were 0.

Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.

We have studied the effect of the newly synthesized agent, roxatidine bismuth citrate (N-[3-(3-(1-piperidinyl-methyl)phenoxy)propyl]-hydroxyacetamide-2- hydroxypropane-1,2,3-tricarboxylate-bismuth(3+) complex), code name MX1, against acetylsalicylic acid (ASA)- and indomethacin-induced gastric mucosal damage in rats. Effects of MX1 (12.5, 50, 125, 184, 250 mg/kg) were compared to the effects of equimolar doses of roxatidine and bismuth subcitrate.

Gastroprotective effect of MX1 (a novel salt of the active metabolite of roxatidine with a complex of bismuth and citric acid) against stress ulcers in rats.

We have studied the effect of the newly synthesized agent MX1, a salt of the active metabolite of the H2-blocker roxatidine with a complex of bismuth and citric acid (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ -2-hydroxypropane-1,2,3-tricarboxilate-bismuth(3+) complex), against restraint stress ulcers in rats (24 h immobilization). The effects of MX1 (12.5, 50, 125, 184 and 250 mg kg-1) were compared with the effects of equimolar doses of roxatidine (6.

Synthesis, gastroprotective, antisecretory and anti-Helicobacter effect of N-[3-(3-(1-piperidinylmethyl) phenoxy)propyl]-hydroxyacetamide 2-hydroxypropane-1,2,3-tricarboxylate bismuth (3+) complex (MX1)-MX1.

MX1 (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ 2-hydroxypropane-1,2,3-tricarboxylate bismuth (3+) complex) is a novel salt of the active metabolite of H2-antagonist roxatidine with a complex of bismuth with citric acid. In a model of ethanol-induced ulcers in male Wistar rats, both roxatidine and the bismuth salt reduced the number and the total length of lesions. Comparison of roxatidine and MX1 at equimolar doses of 160 mumol kg-1 showed a more potent cytoprotective effect of MX1.

Synthesis, antiulcer and antidepressive activity of 4-(4-halophenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolines.

4-(4-halophenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolines 2a-c have been synthesized by two methods and their biochemical and pharmacological properties have been studied. Biochemical investigations showed that all the compounds are strong inhibitors of DA, NE and 5-HT reuptake, the strongest effect being observed with compound 2b (R = Br). 2a-c exhibited a strong antiulcer activity on an experimental model of stress-induced ulcers with minimal doses (0.

Resolution and absolute stereochemistry of 6,7-dimethoxy-4-phenyl- 1,2,3,4-tetrahydroisoquinoline. The crystal structure of the R-hydrochloride salt form.

Stereospecific multistep synthesis and resolution of 6,7-dimethoxy-4- phenyl-1,2,3,4-tetrahydroisoquinoline (3) has been achieved from its racemic base. The absolute configurations of the optical antipodes converted into their hydrochloride salt forms have been determined by X-ray diffractometric analysis, thus permitting assignment of the antipodes as the (+)-(4R)-3 and (-)-(4S)-3 enantiomers. The crystal structures of the two enantiomers are related as mirror images and only the (4R)-3.

[Racemic and optically active 2-chloroethylcarbamoyl derivatives of 7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine: a new structural type of DA, NE and 5-T uptake inhibitors].

The racemic and optically active 2-chloroethylcarbamoyl derivatives of 7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines 6 and 8 were synthesized. The enantiomers of the benzazepine 5 were obtained by consecutive treatment of (+/-)-5 with (-) and (+)-dibenzoyl-tartaric acids. Compounds 6 are strong DA and NE uptake inhibitors while 8 exhibits inhibition towards 5-HT.

A new class of antiulcer drugs. I. Antiulcer effect of AN5, a 4-phenyl-tetrahydroisoquinoline derivative, on different experimental models of ulcer in rats.

The action of AN5 on experimental models of gastric ulcers induced by water-immersion stress, indomethacin and reserpine, or by pylorus ligation in rats has been studied. AN5 supresses the formation of ulcers in all experimental models. The strongest antiulcer effect is shown in relation to water-immersion stress-induced ulcers.

[The effects of compound IZ35 on the beta-adrenergic mediator system].

The biological activity of the compound Iz35, representing rigid conformer of triquinol in respect to the cardiovascular system and smooth musculature, was studied. The arterial blood pressure and heart frequency were recorded in cats and rabbits as well as the tonus of smooth musculature of bronchial tree, uterus and intestines in experiments in vivo and in vitro of rats, guinea pigs and rabbits. It was established that the compound Iz35, administered in a wide range of doses of 0.

Effects of compound IS-35 on intraocular pressure.

The influence of compound IS-35 on intraocular pressure of unanesthetized rabbits was studied. In some cases intraocular pressure was measured with either the tonometer of Schiotz and was calculated in mmHg according to Leydhecker's scale (1973), or with the tonometer of Maclakov. Intraocular pressure was measured before and at 30, 60, 120, 180, 240 and 360 min after topical application of IS-35, timolol and trimetoquinol.

Some analogies between prebiotic thermal conversions of glycine and metabolic pathways.

The reaction schemes suggested earlier for thermal transformation of glycine into amino acids and carboxylic acids are considered in detail. Close analogy with some wide-spread biochemical reactions of amino acids is observed. The pathway suggested has some common stages with the tricarboxylic acid cycle and other metabolic processes.

[The effect of the beta adrenomimetic trimethoquinol and its rigid tetrahydroberberine conformer on histamine liberation induced by compound 48/80 in mast cells].

The effects of the beta 2-adrenomimetic trimethoquinol (TMQ) and one of its rigid tetrahydroprotoberberin conformer - compound Is-35 - on the histamine content and the compound 48/80 induced histamine release have been studied. The histamine content in skin parts of ears and in the whole heart of male rats has been determined spectro-photofluorometrically. TMQ and Is-35 were injected in doses of 3 mumol/kg and compound 48/80 in increasing doses (1, 2 and 3 mg/kg) during 3 successive days.