Metabolism of short-chain fatty acids (SCFA) in the brain, particularly that of acetate, appears to occur mainly in astrocytes. The differential use has been attributed to transport, but the extent to which transmembrane movement of SCFA is mediated by transporters has not been investigated systematically. Here we tested the possible contribution of monocarboxylate transporters to SCFA uptake by measuring fluxes with labelled compounds and by following changes of the intracellular pH in Xenopus laevis oocytes expressing the isoforms MCT1, MCT2 or MCT4.
View Article and Find Full Text PDFLaser Doppler flowmetry (LDF) is a non-invasive method to assess pulpal blood flow (PBF). Dental fracture injuries have been associated with significant PBF reduction The purpose of this study was: (i) to evaluate whether the severity of outcomes of dental fracture injuries may be related to LDF measurements of PBF, and (ii) to investigate whether outcomes of dental fracture injuries may predict PBF levels. The relationship between outcomes and PBF measurements was analyzed in 72 permanent maxillary incisors of 52 consecutive dental trauma patients.
View Article and Find Full Text PDFOral Surg Oral Med Oral Pathol Oral Radiol Endod
December 2004
Objective: Splinting of traumatically displaced or avulsed permanent teeth has been described as an effective modality in the treatment of patients with dental injuries. The purpose of this study was to investigate whether laser Doppler flowmetry (LDF) measurements of pulpal blood flow (PBF) and/or dental injury type may predict treatment outcome of splinting of permanent maxillary incisors.
Study Design: The study comprised 64 patients undergoing dental trauma splinting, who were characterized by the presence of a single permanent maxillary incisor affected by a subluxation, luxation, or avulsion type injury.
rBAT, together with its subunit b(0,+) AT mediates the hetero- and homoexchange of neutral and dibasic amino acids. Since the heteroexchange of dibasic amino acids against neutral amino acids is coupled to net transport of positive charge, this transport is electrogenic. Extracellular addition of histidine could create an inward or an outward current depending on extracellular pH (pH(e)) and cell membrane potential.
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