Publications by authors named "Ivano Lombardo"
Introduction: The latest research in ischaemic stroke pathogenesis is directed to unveil what is inside embolic stroke of undetermined source (ESUS). Whether vulnerable non stenotic carotid plaques (NSTEPS), i.e.
View Article and Find Full Text PDFBackground: Hypoperfusion Intensity Ratio (HIR) is associated with collaterals and outcome in acute ischemic stroke (AIS). We investigated whether a combined assessment of HIR and collaterals could provide an added value.
Methods: Retrospective single-center study, including AIS patients with large vessel occlusion and endovascular treatment 0-24 h from onset.
Article Synopsis
- - The study discusses cerebral collateral circulation, which helps keep at-risk brain tissue alive during strokes and can be improved with reperfusion therapies if blood flow is restored.
- - It compares two techniques used in clinical practice to assess collateral vessels in patients with acute ischemic stroke: single-phase CTA (sCTA) and multi-phase CTA (mCTA), noting that mCTA has a higher predictive value for better outcomes.
- - The review highlights the advantages and disadvantages of both methods, suggesting that mCTA could become the preferred method for evaluating collateral circulation and selecting patients for endovascular treatments.
Vessel Wall Magnetic Resonance Imaging in Cerebrovascular Diseases.
Diagnostics (Basel)
January 2022
Cerebrovascular diseases are a leading cause of disability and death worldwide. The definition of stroke etiology is mandatory to predict outcome and guide therapeutic decisions. The diagnosis of pathological processes involving intracranial arteries is especially challenging, and the visualization of intracranial arteries' vessel walls is not possible with routine imaging techniques.
View Article and Find Full Text PDFThe approach to reperfusion therapies in stroke patients is rapidly evolving, but there is still no explanation why a substantial proportion of patients have a poor clinical prognosis despite successful flow restoration. This issue of futile recanalization is explained here by three clinical cases, which, despite complete recanalization, have very different outcomes. Preclinical research is particularly suited to characterize the highly dynamic changes in acute ischemic stroke and identify potential treatment targets useful for clinical translation.
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