Publications by authors named "Ivannah Pottier"
Article Synopsis
- - Ciguatera poisoning is caused by eating certain marine species contaminated with ciguatoxins (CTXs), which are produced by specific toxic dinoflagellates, and research on these toxins has been ongoing for about 70 years, focusing mainly on the Pacific and Caribbean regions.
- - There currently isn't an official method for measuring ciguatoxins due to the lack of certified reference materials, though some laboratory techniques show promise for detecting these toxins at low levels in fish and have identified a dominant type known as C-CTX-1.
- - New analytical techniques, like advanced mass spectrometry, are enhancing our understanding of ciguatoxins' structures and variations, but more research is needed to fully grasp their toxicity
The contribution of diesel exhaust to atmospheric pollution is a major concern for public health, especially in terms of occurrence of lung cancers. The present study aimed at addressing the toxic effects of a repeated exposure to these emissions in an animal study performed under strictly controlled conditions. Rats were repeatedly exposed to the exhaust of diesel engine.
View Article and Find Full Text PDFThe cuttlefish belongs to the mollusk class Cephalopoda, considered as the most advanced marine invertebrates and thus widely used as models to study the biology of complex behaviors and cognition, as well as their related neurochemical mechanisms. Surprisingly, methods to quantify the biogenic monoamines and their metabolites in cuttlefish brain remain sparse and measure a limited number of analytes. This work aims to validate an HPLC-ECD method for the simultaneous quantification of dopamine, serotonin, norepinephrine and their main metabolites in cuttlefish brain.
View Article and Find Full Text PDFSkin complications were recently reported after carbon-ion (C-ion) radiation therapy. Oxidative stress is considered an important pathway in the appearance of late skin reactions. We evaluated oxidative stress in normal human skin fibroblasts after carbon-ion vs.
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- A new method was developed to measure 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in cell culture fluids using solid-phase extraction and HPLC-ECD.
- The researchers used a technique that adds known amounts of 8-oxodG to counteract interference from the complex cell growth medium.
- After applying this method to X-ray irradiated fibroblasts, they found that radiation increased 8-oxodG levels significantly, indicating it could serve as a biomarker for oxidative stress from moderate X-ray exposure.*
Article Synopsis
- Geotrichum candidum is a common fungus found in various environments, including soil and dairy products, and is primarily used in cheese maturation.
- A recent reclassification identified this species along with several others previously classified under G. geotrichum, and specific DNA markers are used for precise identification.
- Infections from G. candidum are extremely rare, especially in healthy individuals, with most cases occurring in immunocompromised patients, and the overall risk from food consumption is virtually nonexistent.
A barracuda implicated in ciguatera fish poisoning in Guadeloupe was estimated to have an overall flesh toxicity of 15 MUg/g using mouse bioassay. A lipid soluble extract was separated into two toxic fractions, FrA and FrB, on a LH20 Sephadex column eluted with dichloromethane/methanol (1:1). When intraperitoneal injected into mice, FrA provoked symptoms characteristic of slow-acting ciguatoxins, whereas FrB produced symptoms indicative of fast-acting toxins (FAT).
View Article and Find Full Text PDFWe studied the variation in toxin profiles of purified extracts of 10 individual specimens and two pools of ciguateric Caranx latus. High-performance liquid chromatography/mass spectrometry (HPLC/MS) identified in all individual samples at least seven Caribbean ciguatoxins (C-CTXs) comprising C-CTX-1 and its epimer C-CTX-2 ([M+H](+) m/z 1141.58), and five new C-CTX congeners with pseudo-molecular ions at m/z 1141.
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