Publications by authors named "Ivanka Atanasova"
Objective: To compare and analyze how allometrically- and linearly-scaled daily doses of cyclosporine could affect the therapeutic drug monitoring concentrations when applied to 8 infants with liver transplants.
Materials And Methods: Eight infants who underwent liver transplantations were put on twice-daily oral cyclosporine immunosuppressive regimens. After starting therapy, the adjustments of individual daily doses were determined by using therapeutic monitoring of plasma cyclosporine levels by measuring trough concentrations (C) and concentrations at 2 hours after drug administration (C).
Objective: To assess the average bioequivalence of two formulations of metformin after single-dose administration of each treatment to healthy subjects under fasting conditions by assessing the pharmacokinetic measures of systemic exposure and evaluating the confidence intervals (CIs) for each pharmacokinetic parameter.
Design: Randomised, comparative, single-dose, open-label, balanced, two-period, two-treatment, crossover study under fasting conditions.
Participants: 20 healthy volunteers (ten men and ten women) took part in the study.
Objective: To explore the ability of the nonparametric expectation maximisation (NPEM) method of population pharmacokinetic modelling to deal with sparse data in estimating systemic caffeine clearance for monitoring and evaluation of cytochrome P450 (CYP) 1A2 activity.
Design And Participants: Nonblind, single-dose clinical investigation in 34 non-related adult Bulgarian Caucasians (18 women and 16 men, aged between 18 and 62 years) with normal and reduced renal function.
Methods: Each participant received oral caffeine 3 mg/kg.