Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation.

Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis.

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation.

Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7 10 days when they were clinically stable enough to be discharged.