Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial.

Due to its availability and minimal invasive harvesting human adipose tissue-derived extracellular matrix (dECM) is often used as a biomaterial in various tissue engineering and healthcare applications. Next to dECM, cell-derived ECM (cdECM) can be generated by and isolated from in vitro cultured cells. So far both types of ECM were investigated extensively toward their application as (bio)material in tissue engineering and healthcare.

Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response.

Fibronectin coating increases implant biocompatibility by enhancing surface endothelialization via integrin-mediated binding. Surface properties determine the fibronectin orientation and conformation, dictating which ligands are presented, and therefore altering the bioactivity of an implant surface. In this study, polyurethane was treated with oxygen plasma, which allowed for a simultaneous modification of the surface chemistry and topography to modulate fibronectin adsorption.