Design of Magnetic FeO/CeO "Core/Shell"-Like Nanocomposites with Pronounced Antiamyloidogenic and Antioxidant Bioactivity.

"Core/shell" nanocomposites based on magnetic magnetite (FeO) and redox-active cerium dioxide (CeO) nanoparticles (NPs) are promising in the field of biomedical interests because they can combine the ability of magnetic NPs to heat up in an alternating magnetic field (AMF) with the pronounced antioxidant activity of CeO NPs. Thus, this report is devoted to FeO/CeO nanocomposites (NCPs) synthesized by precipitation of the computed amount of "CeO-shell" on the surface of prefabricated FeO NPs. The X-ray diffraction, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy data validated the formation of FeO/CeO "core/shell"-like NCPs, in which ultrafine CeO NPs with an average size of approximately 3-3.

Surface-modified cerium dioxide nanoparticles with improved anti-amyloid and preserved nanozymatic activity.

Cerium dioxide nanoparticles (CeO NPs) are used increasingly in nanotechnology and particularly in biotechnology and bioresearch. Thus, CeO NPs have been successfully tested in vitro as a potential therapeutic agent for various pathologies associated with oxidative stress, including the formation of protein amyloid aggregates. In this study, to increase the anti-amyloidogenic efficiency and preserve the antioxidant potential, the surface of the synthesized CeO NPs is modified with a nonionic, sugar-based surfactant, dodecyl maltoside (DDM), which is known for its high anti-amyloidogenic activity and biocompatibility.

Cerium dioxide nanoparticles synthesized via precipitation at constant pH: Synthesis, physical-chemical and antioxidant properties.

Cerium oxide nanoparticles (CeO NPs) are well known for their application in various fields of industry, as well as in biology and medicine. Knowledge of synthesis schemes, physicochemical and morphological features of nanoscale CeO is important for assessing their antioxidant behavior and understanding the mechanism of oxidative stress and its consequences. The choice of the method of synthesis should be based on the possibility to choose the conditions and parameters for obtaining CeO with controlled dimensions and a ratio of Се/Се on their surface.

The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt.

The amyloidogenic self-assembly of many peptides and proteins largely depends on external conditions. Among amyloid-prone proteins, insulin attracts attention because of its physiological and therapeutic importance. In the present work, the amyloid aggregation of insulin is studied in the presence of cholesterol-based detergent, Chobimalt.

Dual-Functional Antioxidant and Antiamyloid Cerium Oxide Nanoparticles Fabricated by Controlled Synthesis in Water-Alcohol Solutions.

Oxidative stress is known to be associated with a number of degenerative diseases. A better knowledge of the interplay between oxidative stress and amyloidogenesis is crucial for the understanding of both, aging and age-related neurodegenerative diseases. Cerium dioxide nanoparticles (CeO NPs, nanoceria) due to their remarkable properties are perspective nanomaterials in the study of the processes accompanying oxidative-stress-related diseases, including amyloid-related pathologies.

Structural and physical-chemical characterization of redox active CeOnanoparticles synthesized by precipitation in water-alcohol solutions.

A set of cerium dioxide nanoparticles (CeONPs) was synthesized by precipitation in water-alcohol solutions under conditions when the physical-chemical parameters of synthesized NPs were controlled by changing the ratio of the reaction components. The size of CeONPs is controlled largely by the dielectric constant of the reaction solution. An increase of the percentage of Ceions at the surface was observed with a concomitant reduction of the NP sizes.