Epidemiological and clinical characteristics of imported falciparum malaria in the Republic of North Macedonia : A 13-year experience.

Background: Plasmodium falciparum is the leading cause of imported malaria and the most common cause of death in returning travellers.

Aim: To identify the main epidemiological and clinical characteristics of patients with imported falciparum malaria in the Republic of North Macedonia.

Material And Methods: Retrospectively analyzed were the epidemiological and clinical features of 34 patients with imported falciparum malaria who were diagnosed and treated at the university clinic for infectious diseases and febrile conditions in Skopje from 2010 to 2022.

The influence of illness duration before diagnosis on clinical characteristics and outcome in human brucellosis.

Our study assesses the influence of illness duration before establishing the diagnosis of brucellosis and initiating therapy on patients' main clinical characteristics and outcome in an endemic area. The medical files of 297 patients with brucellosis were retrospectively analysed. They were divided into four groups according to illness duration before initiating therapy: <10 days; 11-30 days; 31-90 days; and >90 days.

The changing pattern of fever of unknown origin in the Republic of North Macedonia.

Introduction: The study aimed to compare the etiologic spectrum of diseases causing fever of unknown origin (FUO) and methods for definitive diagnosis in a tertiary care hospital in the Republic of North Macedonia during two different time periods.

Patients And Methods: There were analysed retrospectively the causes for FUO and final diagnostic approaches in 185 patients with classic FUO that were treated at the University Hospital for Infectious Diseases in Skopje during two time periods. Seventy nine patients were treated during 1991 to 1995 and 106 patients during 2011 to 2015.

Evaluation of a rotavirus acute gastroenteritis severity score in hospitalized children over a ten year period in a clinic of infectious diseases, Skopje, R. Macedonia.

Unlabelled: Rotavirus infection is the most common viral infection of the gastrointestinal tract in children with the most severe clinical manifestations and rapidly progressive dehydration, especially in infancy and early childhood. Due to its characteristics of high contagiousness and being widespread in both developed countries and developing countries with a still high fatality rate, active prevention of the disease is recognized as the only successful measure for preventing severe forms of the disease. The assessment of the severity of the clinical picture with the corresponding severity scales, Vesikari or Clark, is essential for interpretation of the success of the applied vaccine.

Doxycycline-rifampin versus doxycycline-rifampin-gentamicin in treatment of human brucellosis.

This prospective, non-randomized trial, compared the efficacy and tolerance of a doxycycline-rifampin regimen, administered for 45 days, versus doxycycline-rifampin given for 45 days plus gentamicin for the first 7-10 days, in the treatment of human brucellosis. Of 238 patients that were initially included in the study, 181 were finally evaluated. Ninety-four were treated with the doxycycline-rifampin and 87 with the doxycycline-rifampin-gentamicin regimens.

Human brucellosis in Macedonia - 10 years of clinical experience in endemic region.

Aim: To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.

Methods: A total of 550 patients with brucellosis treated between 1998 and 2007 were retrospectively assessed for their demographic, epidemiological, and clinical characteristics and outcomes.

Results: Of the 550 patients, 395 (72%) were male.

The role of Brucellacapt test for follow-up patients with brucellosis.

The dynamic of Brucellacapt titers was evaluated in 104 patients with brucellosis with favorable outcome and in 28 patients with persistent illness duration, during the follow-up period of 15 months. In patients with favorable outcome, a permanently decreasing tendency of Brucellacapt titers was evident. Titers< or =1/320 were noted in 27% and 90% of the patients, at the end of the 4th and 15th month, respectively.