Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L.

Background: Epilepsy is a chronic neurological disorder affecting more than 50 million people worldwide, of whom 80% live in low- and middle-income countries. Due to the limited availability of antiseizure drugs (ASDs) in these countries, medicinal plants are the first-line treatment for most epilepsy patients. In Cameroon, a decoction of Cyperus articulatus L.

A study of the flexural strength and surface hardness of different materials and technologies for occlusal device fabrication.

Statement Of Problem: With the emergence of digital technologies, new materials have become available for occlusal devices. However, data are scarce about these different materials and technologies and their mechanical properties.

Purpose: The purpose of this in vitro study was to investigate the flexural strength and surface hardness of different materials using different technologies for occlusal device fabrication, with an emphasis on the digital technologies of computer-aided design and computer-aided manufacturing (CAD-CAM) and 3D printing.

Comprehensive analysis of Cirsium spinosissimum Scop., a wild alpine food plant.

Plants which have been traditionally eaten by alpine populations may provide new opportunities of agricultural development for mountain regions. In this context we investigated the chemical composition of Cirsium spinosissimum (Asteraceae), a perennial thistle. Its receptacles were eaten by shepherds in Valais (Switzerland).

Comprehensive analysis of Phyteuma orbiculare L., a wild Alpine food plant.

Plants which have been traditionally eaten by the alpine population may provide new opportunities for agricultural development in mountain regions. In this context we have investigated the chemical composition of Phyteuma orbiculare (Campanulaceae), a perennial herb whose leaves have been eaten as salad by rural populations in Valais (Switzerland). Extracts of different polarities were subjected to comprehensive metabolite profiling using a dereplication platform combining HPLC-PDA-MS, and offline NMR analysis.

Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

The ability of two plant extracts, Rheum palmatum root extract (RPRE) and Frangula alnus bark extract (FABE), to protect Vitis vinifera leaves from Plasmopara viticola infection was evaluated. These natural products are toxic to the pathogen and induce defence reactions in a susceptible cultivar of V. vinifera (V.