Publications by authors named "Ivan Serra"

Article Synopsis
  • - The study aimed to analyze changes in cartilage and subchondral bone using MRI biomarkers in a rabbit model of osteoarthritis (OA) and link these changes to histological data.
  • - Researchers induced OA by performing ACL transection on rabbits and compared MRI measurements from OA knees with healthy controls, finding significant differences in cartilage and bone metrics like T1 and T2* values.
  • - Results indicated strong correlations between MRI biomarkers and histological changes in both cartilage and subchondral bone, suggesting that MRI can effectively detect OA-related changes.
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Many surgical techniques have been described in the literature to repair chronic tendon or ligament ruptures. Although direct approximation of the edges is the surgical technique of choice, the use of synthetic, fascia lata, semitendinosus muscle, and small intestinal submucosa grafts has been described to repair large defects or augment tenous repairs. The aim of this paper was to present the long-term outcome of two clinical cases using a common calcaneal tendon cadaver allograft with subsequent application of platelet-rich plasma for chronic ruptures diagnosed by ultrasound, with a chronic defect between both edges.

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Osteoarthritis (OA) affects the synovial joint. Animal models commonly used to study the disease and its therapeutic treatment are generally spontaneous or induced. The lack of an animal model representing all types of existing OA requires knowledge about what can be expected from each species and their limitations.

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Introduction: Anterior cruciate ligament (ACL) tears are highly incident injuries in young athletes within our work area. The use of the patellar graft, despite being the treatment of choice, presents post-operative problems such as anterior knee pain, which limits its use and leads to preference being taken for alternative grafts. Our aim was to evaluate if the application of PRGF reduces anterior knee pain in donor site in BTB-ACL reconstruction.

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Purpose: To determine whether the use of plasma rich in growth factors accelerates healing of the donor site in bone-tendon-bone anterior cruciate ligament (ACL) reconstruction (patellar graft). The use of the patellar graft presents post-operative problems such as anterior knee pain, which limits its use and leads to preference being taken for alternative grafts.

Methods: A double-blind, randomized, clinical trial was performed comparing two groups of patients who underwent ACL reconstruction using patellar tendon graft and comparing the use of plasma rich in growth factors at the donor site after graft harvest in terms of local regeneration by ultrasound assessment.

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Unsaturated free fatty acids (FFAs), such as palmitoleic, oleic, linoleic, linolenic and arachidonic acids, have inhibitory actions on mutagenesis. These FFAs in bile may play a role in preventing cholecystopathy and their levels may be influenced by diet. However, the effects of dietary intake on biliary FFAs levels are not known.

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Objectives: To evaluate the association between gallstones and biliary free fatty acids (FFAs) as the first attempt to clarify whether biliary FFAs relate to developing gallbladder cancer (GBC) in Chile, which has the highest mortality rate in the world.

Design And Methods: Gallbladder bile from 21 male and 129 female patients with gallstones from Santiago was collected, and their FFAs were measured. The results were compared with those observed in a similar previous study performed in Niigata and Kochi Prefectures which showed the highest and lowest mortality rates, respectively, for GBC in Japan.

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Objective: To evaluate the use of polyamide bands, manufactured for securing electrical cables, for repair of oblique femoral fractures in rabbits.

Study Design: Experimental study.

Animals: Twelve nulliparous, 21-25-week-old, California female rabbits.

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We explored the risk factors for gallbladder cancer and explanations for its sharp and constant incidence increase in Chile since the 1970s. We compared 114 consecutive patients with verified gallbladder cancer, diagnosed 1992-1995, to 114 matched hospital patients with gallstones, using conditional logistic regression analysis. Low education showed a nonsignificant positive relationship with gallbladder cancer [odds ratio (OR) = 2.

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