Titanium Activates the DNA Damage Response Pathway in Oral Epithelial Cells: A Pilot Study.

Purpose: To evaluate the effect of titanium (Ti) particles on oral epithelial cell homeostasis and the potential of dental implants to release Ti debris upon insertion.

Materials And Methods: Dental implants with varying surface treatments were employed to determine the feasibility of particle release during implant placement as well as the impact of free Ti debris on oral epithelial cells. Ti particles derived from implant surfaces were isolated and cultured in direct contact with normal oral epithelial cells for 48 hours.

Influence of Microtextured Implant Surfaces on Peri-implantitis and Its Treatment: A Preclinical Trial.

Purpose: The prevalence of peri-implantitis has increased significantly, forcing clinicians to search for ways to prevent it. Laser-microtextured surfaces promote soft tissue attachment and provide a tight seal around implants. Hence, the aim of this study was to examine the clinical, radiographic, and histologic features of ligature-induced peri-implantitis, as well as the effect of surgical treatment of these induced peri-implantitis lesions on laser-microtextured implants in a controlled animal model.

In-office fabrication of dental implant surgical guides using desktop stereolithographic printing and implant treatment planning software: A clinical report.

Guided surgery is accepted as the most accurate way to place an implant and predictably relate the implant to its definitive prosthesis, although few clinicians use it. However, recent developments in high-quality desktop 3-dimensional stereolithographic printers have led to the in-office fabrication of stereolithographic surgical guides at reduced cost. This clinical report demonstrates a protocol for using a cost-effective, in-office rapid prototyping technique to fabricate a surgical guide for dental implant placement.

The Effect of Inital-Phase Bone Remodeling on Implant Wound Healing.

This case series aimed to investigate the initial-phase bone remodeling during implant wound healing and to discuss the possible contributing factors. A total of 11 implants with polished collars were placed in premaxillary regions via flapless approach with the aid of computer technology. After 15 months of follow-up, the results suggested that the presence of polished collars triggered bone resorption via a bone remodeling mechanism.

Comparison of Clinical and Radiographic Outcomes of Platform-Switched Implants with a Rough Collar and Platform-Matched Implants with a Smooth Collar: A 1-Year Randomized Clinical Trial.

Purpose: The aim of this study was to evaluate and compare the clinical and radiographic outcomes of single implants with a platform-switched rough collar (PSRC) and a platform-matched smooth collar (PMSC).

Materials And Methods: Twenty-six patients missing a tooth in the anterior maxilla (through the premolars) were randomly assigned to the PSRC or the PMSC group. All implants were placed in a flapless approach and restored with an early loading protocol.

Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial.

Bone engineering of localized craniofacial osseous defects or deficiencies by stem cell therapy offers strong prospects to improve treatment predictability for patient care. The aim of this phase 1/2 randomized, controlled clinical trial was to evaluate reconstruction of bone deficiencies of the maxillary sinus with transplantation of autologous cells enriched with CD90+ stem cells and CD14+ monocytes. Thirty human participants requiring bone augmentation of the maxillary sinus were enrolled.

Optimized cell survival and seeding efficiency for craniofacial tissue engineering using clinical stem cell therapy.

Traumatic injuries involving the face are very common, yet the clinical management of the resulting craniofacial deficiencies is challenging. These injuries are commonly associated with missing teeth, for which replacement is compromised due to inadequate jawbone support. Using cell therapy, we report the upper jaw reconstruction of a patient who lost teeth and 75% of the supporting jawbone following injury.

Effectiveness of three different alveolar ridge preservation techniques: a pilot randomized controlled trial.

The aim of this pilot study was to obtain preliminary data regarding the effectiveness of three different alveolar ridge preservation modalities as compared with a control. Subjects in need of single-rooted tooth extraction were recruited and randomly allocated to one of four treatment groups: group 1 (control)--collagen plug; group 2--socket grafting and polytetrafluoroethylene (PTFE) barrier; group 3--socket grafting, buccal overbuilding, and PTFE barrier; group 4--socket grafting, collagen barrier, and PTFE barrier. The grafting material used in all groups was an allograft.

Histomorphometric analysis of bone regeneration using a dual layer of membranes (dPTFE placed over collagen) in fresh extraction sites: a canine model.

In untreated extraction sockets, buccal bone remodeling compromises the alveolar ridge width. The aim of this study was to histologically assess the efficacy of using a dual layer of membranes (high-density polytetrafluoroethylene [dPTFE] placed over collagen) for ridge preservation in fresh extraction sites. Eight beagle dogs were used.

A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement surgery: I. Clinical and radiographic parameters.

Objectives: Sandwich bone augmentation (SBA) has been proposed to augment the width of edentulous ridges for implant placement. This study aimed to investigate the effect of a membrane on SBA for the regeneration of buccal implant dehiscence defects.

Material And Methods: Twenty-six healthy patients, each with a single defect, were randomly assigned into two groups.

Effect of flapless surgery on single-tooth implants in the esthetic zone: a randomized clinical trial.

Background: Implant therapy is a highly predictable treatment option; however, insufficient data exist to show whether flapless implant surgery provides better esthetic outcomes and less bone loss than implant surgery with a flap approach.

Methods: In this randomized, controlled study comparing the flapless and traditional flap protocol for implant placement, 24 patients received a single implant in the anterior maxillary region. A cone beam computed tomography-aided surgical guide was used for implant placement surgery for both groups.

The success rate of narrow body implants used for supporting immediate provisional restorations: a pilot feasibility study.

Background: Implants were first designed to be used in the reconstruction of edentulous mandibles. However, with the technological advancement, enormous changes were made to improve the implant design and surface characteristics leading to the wide use of implants in the replacement of missing teeth. During the transition from an edentulous span to a fixed prosthesis, narrow body implants (NBIs) have been proposed to enhance patient comfort and function.

Efficacy of acellular dermal matrix and coronally advanced flaps for the treatment of induced gingival recession defects: a histomorphometric study in dogs.

Background: Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs.

Methods: In eight beagle dogs, a critical-size labial GR defect was surgically induced on bilateral maxillary cuspids under general anesthesia.

Influence of lateral window dimensions on vital bone formation following maxillary sinus augmentation.

Purpose: The aim of this study was to evaluate the influence that lateral window dimensions may have on maxillary sinus augmentation outcomes.

Materials And Methods: Patients requiring maxillary sinus augmentation by a lateral window approach and delayed implant placement were recruited in this study. Approximate window dimensions (AWD) were calculated in mm2 at the time of the surgical intervention.

Efficacy of using a dual layer of membrane (dPTFE placed over collagen) for ridge preservation in fresh extraction sites: a micro-computed tomographic study in dogs.

Objective: To assess if overbuilding the buccal plate or using a dual-layer socket grafting technique prevents alveolar bone resorption and enhances final ridge width, height, and volume after tooth loss in an animal model.

Material And Methods: In eight beagle dogs bilateral second (P2)-, third (P3)-, and fourth (P4) premolars were endodontically treated. All bilateral mandibular first premolars and distal roots of P2, P3, and P4 were hemisectioned and atraumatically extracted.

Analysis of the influence of residual alveolar bone height on sinus augmentation outcomes.

Introduction: Maxillary sinus augmentation is a predictable implant site development technique for posterior atrophic maxillary ridges. However, graft consolidation requires adequate angiogenesis and migration of osteogenic cells from native bone. Therefore, the amount of residual bone height (RBH) may play a role in the rate of graft maturation.

Hard and soft tissue changes after crestal and subcrestal immediate implant placement.

Background: The purpose of this study is to assess the influence of the placement level of implants with a laser-microtextured collar design on the outcomes of crestal bone and soft tissue levels. In addition, we assessed the vertical and horizontal defect fill and identified factors that influenced clinical outcomes of immediate implant placement.

Methods: Twenty-four patients, each with a hopeless tooth (anterior or premolar region), were recruited to receive dental implants.

Cross-sectional analysis of the mandibular lingual concavity using cone beam computed tomography.

Objectives: To study the prevalence and the degree of lingual concavity in the edentulous first molar region from cone beam computed tomography (CBCT) scans of the mandibles.

Material And Methods: Qualified cross-sectional images in mandibular first molar edentulous region taken from CBCT were selected. The mandible morphology 2 mm above the inferior alveolar canal (IAC) was classified into the convex (C), parallel (P) and undercut (U) type, based on the presence of lingual concavity and the shape of alveolar ridge.

Risk assessment of lingual plate perforation in posterior mandibular region: a virtual implant placement study using cone-beam computed tomography.

Background: Lingual plate perforation at the time of implant placement in posterior mandible is a potential surgical complication, and presence of a lingual concavity is considered a risk factor. Little is known about the spatial relationship between implant and lingual plate. The role of lingual concavity in the risk of lingual perforation has not yet been fully studied.

The influence of the bucco-palatal distance on sinus augmentation outcomes.

Background: Maxillary sinus augmentation is one of the most reliable implant site development options to increase vertical bone height. However, graft consolidation requires adequate angiogenesis and migration of cells involved in osteogenesis and bone remodeling. It is speculated that these biologic events are greatly determined by the dimensions of the maxillary sinus cavity.

Immediate implant placement: positives and negatives.

Background: An immediate implant approach based on the International Congress of Oral Implantologists Glossary of Implant Dentistry is defined as an implant placement immediately after tooth extraction. This allows clinicians to reduce the number of surgical procedures, resulting in shorter treatment times. However, immediate implant placement may also lead to a higher implant failure rate, inability to predict future soft and hard tissue level, and difficulty in achieving implant primary stability.