Potential Regulation of by miR-129-5p and miR-3613-3p and Their Prognostic Value in Gastric Cancer.

Gastric cancer (GC) remains the most common malignant tumor of the gastrointestinal tract and one of the leading causes of cancer-related deaths worldwide. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), are involved in the pathogenesis and progression of GC and, therefore, may be potential diagnostic and prognostic biomarkers. Our work was aimed at investigating the predicted regulation of by miR-129-5p and miR-3613-3p and the clinical value of their aberrant expression in GC.

Dose-Response Effect of Various Concentrations of Cl-Containing Water-Soluble Derivatives of C Fullerenes on a Selective Regulation of Gene Expression in Human Embryonic Lung Fibroblasts (HELF).

Background: The new synthesized water-soluble derivatives of C fullerenes are of a great interest to researchers since they can potentially be promising materials for drug delivery, bioimaging, biosonding, and tissue engineering. Surface functionalization of fullerene derivatives changes their chemical and physical characteristics, increasing their solubility and suitability for different biological systems applications, however, any changes in functionalized fullerenes can modulate their cytotoxicity and antioxidant properties. The toxic or protective effect of fullerene derivatives on cells is realized through the activation or inhibition of genes and proteins of key signaling pathways in cells responsible for regulation of cellular reactive oxygen species (ROS) level, proliferation, and apoptosis.

DPPM-Bridged Binuclear Pt(II) Pincer Complexes: Chemistry, Structure, and Photophysics in Solution Revisited.

A series of luminescent binuclear ([dppm{Pt(NNC)}]) and mononuclear ([PPhPt(NNC)]) complexes containing pincer ligands were synthesized and characterized. Photophysical characteristics of both types of complexes were studied in dichloromethane solution. In the solid phase, the binuclear compounds adopt a syn configuration where the {Pt(NNC)} fragments are held together due to intramolecular Pt-Pt bonding and π-stacking of the pincer ligand aromatic systems.

Hydrothermally Synthesized ZnCr- and NiCr-Layered Double Hydroxides as Hydrogen Evolution Photocatalysts.

The layered double hydroxides (LDHs) of transition metals are of great interest as building blocks for the creation of composite photocatalytic materials for hydrogen production, environmental remediation and other applications. However, the synthesis of most LDHs is reported only by the conventional coprecipitation method, which makes it difficult to control the catalyst's crystallinity. In the present study, ZnCr- and NiCr-LDHs have been successfully prepared using a facile hydrothermal approach.

Effects of Aqueous Dispersions of C, C, and Gd@C Fullerenes on DNA Oxidative Damage/Repair and Apoptosis in Human Embryonic Lung Fibroblasts.

Fullerenes and metallofullerenes play an active role in homeostasis of reactive oxygen species and may cause oxidative damage to cells. As pristine fullerenes are a basis for derivatization, studying oxidative DNA damage/repair and apoptosis is important in terms of genotoxicity and cytotoxicity for their biomedical application. Aqueous dispersions of C, C, and Gd@C (5 nM and 1.

Genetic Divergence of Vibrio vulnificus Clinical Isolates with Mild to Severe Outcomes.

The marine bacterium Vibrio vulnificus infects humans via food or water contamination, leading to serious manifestations, including gastroenteritis, wound infections, and septic shock. Previous studies suggest phylogenetic Lineage 1 isolates with the v allele of the gene cause human infections, whereas Lineage 2 isolates with the allele are less pathogenic. Mouse studies suggest that some variants of the primary toxin could drive more serious infections.

Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria.

Background: The histidine metabolism and transport (his) genes are controlled by a variety of RNA-dependent regulatory systems among diverse taxonomic groups of bacteria including T-box riboswitches in Firmicutes and Actinobacteria and RNA attenuators in Proteobacteria. Using a comparative genomic approach, we previously identified a novel DNA-binding transcription factor (named HisR) that controls the histidine metabolism genes in diverse Gram-positive bacteria from the Firmicutes phylum.

Results: Here we report the identification of HisR-binding sites within the regulatory regions of the histidine metabolism and transport genes in 395 genomes representing the Bacilli, Clostridia, Negativicutes, and Tissierellia classes of Firmicutes, as well as in 97 other HisR-encoding genomes from the Actinobacteria, Proteobacteria, and Synergistetes phyla.

Photocatalytic Hydrogen Production from Aqueous Solutions of Glucose and Xylose over Layered Perovskite-like Oxides HCaNbO, HLaTiO and Their Inorganic-Organic Derivatives.

Nowadays, the efficient conversion of plant biomass components (alcohols, carbohydrates, etc.) into more energy-intensive fuels, such as hydrogen, is one of the urgent scientific and technological problems. The present study is the first one focused on the photoinduced hydrogen evolution from aqueous D-glucose and D-xylose using layered perovskite-like oxides HCaNbO, HLaTiO, and their organically modified derivatives that have previously proven themselves as highly active photocatalysts.

Effects of Aqueous Dispersions of C, C and Gd@C Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways.

Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves and as a basis for chemical modification. As reactive oxygen species homeostasis plays a vital role in cells, the study of their effect on genes involved in oxidative stress and anti-inflammatory responses are of particular importance.

Methods: Human fetal lung fibroblasts were incubated with aqueous dispersions of C, C, and Gd@C in concentrations of 5 nM and 1.

Study of alkylamine Intercalated Layered Perovskite-Like Niobates HCaNbO as Photocatalysts for Hydrogen Production From an Aqueous Solution of Methanol.

A series of hybrid niobates HCaNbO×RNH, containing -alkylamines (R = Me, Et, Pr, Bu, Hx, Oc) intercalated into the interlayer space, has been thoroughly studied concerning the photocatalytic hydrogen production from a model aqueous solution of methanol for the first time. All the hybrid photocatalysts were synthesized by the conventional ceramic technique followed by protonation and intercalation of -alkylamines. The products were characterized using XRD, Raman, IR and diffuse reflectance spectroscopy, TGA, CHN-analysis and SEM.

Layered Titanate HNdTiO Intercalated With -Butylamine: A New Highly Efficient Hybrid Photocatalyst for Hydrogen Production From Aqueous Solutions of Alcohols.

A layered perovskite-type oxide intercalated with -butylamine is reported as an efficient photocatalyst for hydrogen production from aqueous solutions of alcohols for the first time. The hybrid photocatalyst HNdTiO×BuNH was synthesized by solid-state ceramic method followed by protonation, intercalation of methylamine and subsequent substitution by -butylamine. The product was characterized by powder XRD, TGA, STA-MS, DRS, IR, and Raman spectroscopy, CHN analysis, SEM.

The Effect of Hydrogen on Martensite Transformations and the State of Hydrogen Atoms in Binary TiNi-Based Alloy with Different Grain Sizes.

The analysis presented here shows that in B2-phase of TiNi (at%) alloy, hydrogenation with further aging at room temperature decreases the temperatures of martensite transformations and then causes their suppression, due to hydrogen diffusion from the surface layer of specimens deep into its bulk. When hydrogen is charged, it first suppresses the transformations B2↔B19' and R↔B19' in the surface layer, and when its distribution over the volume becomes uniform, such transformations are suppressed throughout the material. The kinetics of hydrogen redistribution is determined by the hydrogen diffusion coefficient D, which depends on the grain size.

Draft Genome Sequences of Two Strains Associated with Gastroenteritis after Raw Seafood Ingestion in Colorado.

is a Gram-negative pathogen associated with gastrointestinal and wound infections after exposure to raw seafood or contaminated waters. We report here the whole-genome sequences of two stool isolates (CDC-AM50933 and CDC-AM43539) from patients in Colorado presenting with gastroenteritis after ingesting raw seafood.