Role of the cGAS/STING pathway in the control of infection acquired through the respiratory route.

Despite the importance of the respiratory route for transmission, the lung immune response to this pathogen is scarcely characterized. We investigated the role of the cGAS/STING pathway of microbial DNA recognition in the control of respiratory infection. After infection, CFU numbers were significantly higher in alveolar macrophages (AM) and lung explants from STING KO mice than in samples from wild type (WT) mice, but no difference was observed for cGAS KO samples.

Pathogenesis and immune response in Brucella infection acquired by the respiratory route.

Brucella infection is frequently acquired through the respiratory route. The pathogen disseminates systemically from the lungs to infect peripheral organs. In this review we summarize the existing data on the pathogenesis of inhalational Brucella infection, the pulmonary immune response to the pathogen, and potential strategies for inducing protective lung immunity.

Proliferates in Decidualized and Non-Decidualized Human Endometrial Cells Inducing a Proinflammatory Response.

spp. have been associated with abortion in humans and animals. Although the mechanisms involved are not well established, it is known that placental infection is accompanied by inflammatory phenomena.

The BtaF Adhesin Is Necessary for Full Virulence During Respiratory Infection by and Is a Novel Immunogen for Nasal Vaccination Against Infection.

enters their hosts mostly through mucosae from where it spreads systemically. Adhesion to extracellular matrix (ECM) components or to host cells is important for the infectious process, and is mediated by several adhesins, including the BtaF trimeric autotransporter. Although Th1 responses and gamma interferon (IFN-γ) are important for protection, antibodies able to block adhesions might also contribute to prevent infection.

IL-1R and Inflammasomes Mediate Early Pulmonary Protective Mechanisms in Respiratory Infection.

spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory infection is unknown.