Publications by authors named "Ivan Kong"
The turnover rate of melanogenesis in retinal pigment epithelium (RPE) and its molecular signaling remain unclear. This study aimed to investigate the role of cholinergic signaling in the process of melanogenesis of cultured RPE cells. Here, a human retinal pigment epithelia cell line, ARPE-19 cell, was used to study the process of melanogenesis.
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- - Cholinergic urticaria is a skin condition marked by red patches and hives that arise from triggers like exercise, sweating, and stress, potentially due to decreased levels of the enzyme acetylcholinesterase (AChE).
- - This decrease in AChE leads to excess acetylcholine (ACh) leaking into the skin, causing mast cells to release histamine and trigger inflammatory responses.
- - Research shows that exposure to ultraviolet B (UVB) light lowers AChE levels in skin cells by promoting specific micro-RNAs (miR-132 and miR-212), suggesting that UVB exposure plays a role in worsening cholinergic urticaria.