The real-time prediction and estimation of the spread of diseases, such as COVID-19 is of paramount importance as evidenced by the recent pandemic. This work is concerned with the distributed parameter estimation of the time-space propagation of such diseases using a diffusion-reaction epidemiological model of the susceptible-exposed-infected-recovered (SEIR) type. State estimation is based on continuous measurements of the number of infections and deaths per unit of time and of the host spatial domain.
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