Publications by authors named "Ivan Evshin"
Background: Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed that some cancer cells may lose sensitivity to this compound.
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- Rat pluripotent stem cells, including embryonic (ESCs) and induced pluripotent stem cells (iPSCs), show promise for research on early mammalian development, but data on rat pluripotency and differentiation methods are limited.
- The study utilized RNA-Seq to analyze the transcriptomes of rat ESCs and iPSCs, revealing that they are quite similar and distinct from differentiated cells, along with a notable X-chromosome reactivation during reprogramming.
- A new monolayer differentiation protocol was developed to better understand X-chromosome inactivation dynamics and facilitate the creation of specific cell types for biomedical applications.