Case report of large solitary skull base metastasis from renal cell carcinoma as initial clinical presentation: Radiological findings and differentials.

A 58-year-old male with good past health presented with headache and visual disturbance for 1 month. Computed tomography (CT) and magnetic resonance imaging (MRI) were performed, showing a large aggressive midline mass with epicenter at the skull base and sellar-suprasellar region. There was marked heterogenous enhancement and intratumoral calcifications.

Undercounting of large trucks in federal and state crash databases: Extent of problem and how to improve accuracy of truck classifications.

Objective: Prior research suggested that single-unit trucks are undercounted when using vehicle body codes in the Fatality Analysis Reporting System (FARS). This study explored the extent of the misclassification and undercounting problem for crashes in FARS and state crash databases.

Methods: Truck misclassifications for fatal crashes were explored by comparing the Trucks Involved in Fatal Accidents (TIFA) database with FARS.

SAOS-2 osteosarcoma cells bind fibroblasts via ICAM-1 and this is increased by tumour necrosis factor-α.

We recently reported exchange of membrane and cytoplasmic markers between SAOS-2 osteosarcoma cells and human gingival fibroblasts (h-GF) without comparable exchange of nuclear markers, while similar h-GF exchange was seen for melanoma and ovarian carcinoma cells. This process of "cellular sipping" changes phenotype such that cells sharing markers of both SAOS-2 and h-GF have morphology intermediate to that of either cell population cultured alone, evidencing increased tumour cell diversity without genetic change. TNF-α increases cellular sipping between h-GF and SAOS-2, and we here study binding of SAOS-2 to TNF-α treated h-GF to determine if increased cellular sipping can be accounted for by cytokine stimulated SAOS-2 binding.

(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus.

Hydrophobins are fungal proteins characterised by their amphipathic properties and an idiosyncratic pattern of eight cysteine residues involved in four disulphide bridges. The soluble form of these proteins spontaneously self-assembles at hydrophobic/hydrophilic interfaces to form an amphipathic monolayer. The RodA hydrophobin of the opportunistic pathogen Aspergillus fumigatus forms an amyloid layer with a rodlet morphology that covers the surface of fungal spores.

Safety challenges and oversight in the motorcoach industry: attitudes and perceptions of drivers, roadside inspectors, and federal investigators.

Interstate motorcoach travel has been the fastest-growing transportation mode in recent years. To identify challenges to monitoring compliance with motorcoach safety regulations and to examine factors affecting safety, four focus groups with a total of 32 participants were conducted during 2011, one with federal safety investigators, one with state motor carrier inspectors, and two with motorcoach drivers. Investigators and inspectors expressed concern about falsified logbooks, inadequate sleep among motorcoach drivers, hazards from speeding motorcoaches, practices by motorcoach carriers to mask ownership and avoid oversight, and difficulties keeping up with rapid motorcoach industry growth.

Characteristics of interstate motorcoach carriers with elevated rates of crashes and inspection violations.

Widely-publicized fatal motorcoach crashes have caused public concern about their safety. This study estimated crash and violation rates among interstate motorcoach carriers based on 2005-2011 data obtained from the Federal Motor Carrier Safety Administration (FMCSA). Motorcoach carriers with relatively high crash and violation rates were compared with those with better safety records.

Optimizing secondary prevention: Statin prescribing across East and West London in accordance with NICE guidelines.

Objectives: Statins are a well-known primary and secondary prevention drug for cardiovascular disease and NICE guidelines have been issued to identify key indicators for their use. An audit looking into statin prescribing for medical inpatients was carried out in two geographically distinct London hospitals.

Design: A prospective inpatient audit of medical prescription charts was performed.

Declines in fatal crashes of older drivers: changes in crash risk and survivability.

Objectives: Previous research has found that older driver fatal crash involvement rates per licensed driver declined substantially in the United States during 1997-2006 and declined much faster than the rate for middle-age drivers. The current study examined whether the larger-than-expected decline for older drivers extended to nonfatal crashes and whether the decline in fatal crash risk reflects lower likelihood of crashing or an improvement in survivability of the crashes that occur.

Methods: Trends in the rates of passenger vehicle crash involvements per 100,000 licensed drivers for drivers 70 and older (older drivers) were compared with trends for drivers ages 35-54 (middle-age drivers).

Creating a geospatial database of risks and resources to explore urban adolescent substance use.

This article illustrates the methodology of creating a comprehensive geospatial database in order to systematically understand the social ecology of risk and protection for urban youth. The challenges and future opportunities involved with this complex work were reviewed, and specific examples were provided to guide researchers. Data were collected from a Washington, DC adolescent substance abuse treatment sample to construct a geospatial database to evaluate urban youths' social environmental risk and resources.

Exploring the declines in older driver fatal crash involvement.

The number of drivers 70 and older is growing at a fast pace, and older drivers are keeping their licenses longer and driving more. Despite these trends, older driver crash deaths and fatal crash involvements declined steadily during the decade 1997-2006 following an upward trend for many years. The present study explored various facets of the decline in older driver fatal crash involvement during 1997-2006.

Traffic speeds associated with implementation of 80 mph speed limits on West Texas rural interstates.

Problem: In 2006 Texas raised the daytime speed limit for passenger vehicles on segments of I-10 and I-20 from 75 to 80 mph.

Methods: Traffic speeds were measured before and 3, 12, and 16 months after the limit was changed.

Results: During the 16-month period following the speed limit increase, mean speeds of passenger vehicles on I-20 increased by 9 mph relative to the comparison road, where no speed limit change occurred and traffic speeds declined.

Substance use, social networks, and the geography of urban adolescents.

This article demonstrates a research strategy and prevention methodology for substance using urban youth that incorporates individual, social, and geographical parameters to systematically understand the ecology of risk and protection for urban youth. The primary goal of this study was to describe and analyze substance using and nonusing urban adolescents' social networks; risky and protective settings where they socialize; and the relationship to health outcomes such as substance use, depression, and stress. Geographic Information Systems (GIS) derived spatial relationships and analyses between the specific locations where the teens are active, their subjective ratings of these locations, and objective environmental risk data.

Physician accessibility: an urban case study of pediatric providers.

Social disparity in the spatial distribution of healthcare providers in urban areas is a recognized problem. However, efforts to quantify the problem have been hampered by a lack of satisfactory measurements and methods. We revive and enhance a strategy based on provider density, proposed nearly three decades ago.