Publications by authors named "Ivan Andrew"
Article Synopsis
- Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
- The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
- Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
Article Synopsis
- * In a study analyzing RNAseq data from different strains, deletion of RofA in M1 strains affected expression levels of several genes, with distinct impacts on each lineage regarding non-pilus genes.
- * Changes in gene expression due to specific SNPs in the M1 lineage didn't significantly affect an M1 strain, but reversing those SNPs resulted in notable transcriptomic changes similar to those caused by RofA deletion, indicating a complex regulatory role that requires further exploration.
Cardiac fibrosis is a common pathological process in heart disease, representing a therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac fibrosis and was recently shown to be dependent on interleukin 11 (IL11) for its profibrotic effects in fibroblasts. In the opposite direction, recombinant human IL11 has been reported as anti-fibrotic and anti-inflammatory in the mouse heart.
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- Genotype 1, particularly the M1 sublineage, is a virulent strain linked to scarlet fever outbreaks in England during 2015/2016, marked by 27 specific SNPs in its genome.
- Comparative analyses revealed only seven differentially expressed genes in M1 compared to other strains, with key metabolic changes influencing pathogen behavior.
- The evolution of M1 is attributed to a stepwise accumulation of SNPs that enhance its fitness, allowing it to outcompete other related strains, despite having similar toxin production capabilities.
Despite their latent neurogenic potential, most normal parenchymal astrocytes fail to dedifferentiate to neural stem cells in response to injury. In contrast, aberrant lineage plasticity is a hallmark of gliomas, and this suggests that tumor suppressors may constrain astrocyte dedifferentiation. Here, we show that p53, one of the most commonly inactivated tumor suppressors in glioma, is a gatekeeper of astrocyte fate.
View Article and Find Full Text PDFCellular barcoding techniques are powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been broadly applied to protozoan parasites, which have unique genomic structures and virulence strategies compared with viral and bacterial pathogens. Here, we present a CRISPR-based method to barcode protozoa, which we successfully apply to and .
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