Useful histological findings in incisional biopsies of oral squamous cell carcinoma.

Introduction: Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers.

Objective: The aim of this study was to investigate the histopathological features of OSCC specimens obtained from incisional biopsies and to alert clinicians to the importance of more representative biopsies.

Methods: Forty-eight OSCC samples were obtained from incisional biopsies and classified by Bryne’s score.

MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.

The present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation. Twenty-eight cases of OSCC, 9 of tumor-free resection margins (TM), and 4 of non-neoplastic oral mucosa (NNM) were subjected to immunohistochemistry to detect the expression of proteins MCM3 and Ki-67. All OSCCs demonstrated positivity for both proteins.

Density of mast cells and microvessels in minor salivary gland tumors.

The aim of this study was to investigate the density of mast cells and microvessels in minor salivary gland tumors. Forty-one cases of minor salivary gland tumors (pleomorphic adenoma, n = 10; adenoid cystic carcinoma, n = 11; mucoepidermoid carcinoma, n = 10; and polymorphous low-grade adenocarcinoma) were investigated using immunohistochemistry for mast cell tryptase and von-Willebrand factor. Density of mast cells was higher in mucoepidermoid carcinoma; however, no differences in the number of these cells were observed between the different types of tumors (p > 0.

Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy.

Surgery is the preferred modality for curative treatment of recurrent laryngeal cancer after failure of nonsurgical treatments. Patients with initial early-stage cancer experiencing recurrence following radiotherapy often have more advanced-stage tumors by the time the recurrence is recognized. About one third of such recurrent cancers are suitable for conservation surgery.

Second salvage surgery for re-recurrent oral cavity and oropharynx carcinoma.

Background: Salvage surgery is considered the best treatment approach for patients with recurrent oral carcinoma. Unfortunately, 50% to 60% of the patients who undergo salvage surgery will develop further locoregional recurrence, and they are not usually considered for further treatment. Our aim in this study was to report our experience with a second salvage surgery for selected patients with re-recurrent oral cavity and oropharyngeal squamous cell carcinoma (SCC).

Biological markers and prognosis in recurrent oral cancer after salvage surgery.

Objective: To analyze the prognostic effect of epidermal growth factor receptor (EGFR), matrix metalloproteinases 2 and 9, and vascular endothelial growth factor expression in patients with locally recurrent oral carcinoma after salvage surgery.

Design: Retrospective cohort study. Settings Tertiary center cancer hospital.

Preservation of the internal jugular vein in the radical treatment of node-positive neck--is it safe?

Background: The aim of this study was to evaluate risk factors of neck recurrence in patients with pN+ necks submitted to a modified or a classic radical neck dissection and the safety of preserving the internal jugular vein in the treatment of a subgroup of these patients.

Methods: The medical records of 311 untreated patients with squamous cell carcinoma of the oral cavity (106 cases), oropharynx (95 cases), larynx (49 cases), and hypopharynx (61 cases) were reviewed. Their clinical stages (CS) were CS II in 1%, CS III in 19.

Internal jugular vein preservation in neck dissection for pN1-N2c oral and oropharyngeal carcinoma.

Purpose: The aim of this study is to evaluate risk factors of neck recurrence in patients with pN1-N2 neck stage, submitted to a modified radical neck dissection with preservation of the internal jugular vein.

Materials And Methods: We reviewed the medical records of 72 patients with squamous cell carcinoma of the oral cavity (43 cases) and oropharynx (29 cases). The clinical stage of the neck was N1 in 23 cases and N2a-c in 49.

Prognostic factors in salvage surgery for recurrent oral and oropharyngeal cancer.

Background: Therapeutic decisions in recurrent oral and oropharyngeal squamous carcinoma (SCC) remain controversial.

Methods: Two hundred forty-six consecutive patients who underwent salvage surgery for recurrent squamous cell carcinoma (SCC) of the oral cavity and oropharynx were studied. The tumor sites were lip, 33 cases; oral cavity, 143; oropharynx, 70.

Treatment results on advanced neck metastasis (N3) from head and neck squamous carcinoma.

Objective: To analyze the long-term results of patients with N3 neck metastasis from squamous carcinoma of the head and neck.

Study Design: This study is based on the analysis of a retrospective cohort of 224 previously untreated patients with squamous cell carcinoma of the head and neck and lymph node metastasis sized greater than 6 cm (N3) who were evaluated from 1981 to 1996.

Results: Fifty-four patients (24.

Postoperative complications after en bloc salvage surgery for head and neck cancer.

Objective: To analyze the frequency of and risk factors for postoperative complications after en bloc salvage surgery for head and neck cancer.

Design: Retrospective cohort study.

Setting: Patients were evaluated from February 7, 1990, to November 17, 1999, in a tertiary cancer center hospital.

Distribution of metastatic lymph nodes in oropharyngeal carcinoma and its implications for the elective treatment of the neck.

Objectives: To analyze the distribution of lymph node metastases in patients with oropharyngeal squamous cell carcinoma and improve the rationale for elective treatment of the neck.

Design And Setting: Retrospective cohort study of patients evaluated from 1990 to 1998 in a tertiary cancer care center.

Patients: The 81 consecutive patients who were identified from the hospital database.