Publications by authors named "Ivailo L Tournev"
Background: Telemedicine (TM) contributes to bridge the gap between healthcare facilities and patients' homes with neuromuscular disease (NMD) because of mobility issues. However, its deployment is limited due to difficulties evaluating subtle neurological signs such as mild weakness or sensory deficits. The COVID-19 pandemic has disrupted healthcare delivery worldwide, necessitating rapid measures implementation by health care providers (HCPs) to protect patients from acquiring SARS-CoV-2 while maintaining the best care and treatment.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated vutrisiran, an RNA therapy aimed at reducing transthyretin (TTR) production, in patients with hereditary transthyretin (ATTRv) amyloidosis affecting the nerves.
- The phase 3 HELIOS-A trial involved 164 patients, comparing vutrisiran (administered every 3 months) to patisiran (administered every 3 weeks) and an external placebo group, assessing various health outcomes over 18 months.
- Results showed that vutrisiran led to significant improvements in neuropathy scores and quality of life compared to placebo, with a good safety profile and no serious drug-related complications.*