Publications by authors named "Iva L Hoffmann"
Central nervous system (CNS) tumors are the second most frequent type of neoplasm in childhood and adolescence, after leukemia. Despite the incorporation of molecular classification and improvement of protocols combining chemotherapy, surgery, and radiotherapy, CNS tumors are still the most lethal neoplasm in this age group. Mass spectrometry imaging (MSI) is a powerful tool to map the distribution of molecular species in tissue sections.
View Article and Find Full Text PDFEmbryonic tumors share few recurrent mutations, suggesting that other mechanisms, such as aberrant DNA methylation, play a prominent role in their development. The loss of imprinting (LOI) at the chromosome region 11p15 is the germline alteration behind Beckwith-Wiedemann syndrome that results in an increased risk of developing several embryonic tumors. This study analyzed the methylome, using EPIC Beadchip arrays from 99 sporadic embryonic tumors.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on Burkitt lymphoma affecting the head and neck (BLHN) in pediatric patients from Africa, Guatemala, and Brazil, revealing common clinical and anatomical characteristics across these regions.
- - Among the 52 cases reviewed, a significant majority (82.69%) were children, with common symptoms including tumors, cervical lymphadenopathy, and bone destruction, and typical features associated with Burkitt lymphoma were observed.
- - Immunohistochemical analysis showed uniform expression of specific markers like CD20 and high Ki-67 indices, with Epstein-Barr virus (EBV) present in about 62% of cases, indicating similarities in the disease profile across the studied populations.
Objective: To describe the clinical, demographic, anatomopathological, molecular, and survival characteristics of patients with medulloblastoma.
Methods: Retrospective study based on patient information obtained from the review of medical records. Overall and event-free survival were analyzed using the Kaplan-Meier estimator, and the curves were compared by the log-rank test.
Background: Incidence and mortality rates of childhood cancer represent a global public health issue, however, the worldwide prevalence of head and neck cancer in pediatric patients (HNCPP) is still unknown. Therefore, this study aimed to describe the frequency and distribution of HNCPP worldwide.
Methods: A specific search strategy was performed using MEDLINE, Scopus, and EMBASE to include studies based on hospital records, national cancer registries, and pathology files.
Objective: The aim of this study is to determine the relative frequency, demographic distribution and clinicopathological features of pediatric oral and maxillofacial cancer (POMC).
Methods: Medical records were retrospectively reviewed for all cancer cases diagnosed from 1986 to 2016 affecting patients aged 19 years and younger. Demographic variables, anatomical site, and histopathological diagnoses were collected and analyzed by descriptive statistics.
Demographic and clinicopathologic distribution of head and neck malignant tumors in pediatric patients from a Brazilian population: A retrospective study.
J Oral Pathol Med
August 2018
Article Synopsis
- The study investigates the rising incidence of pediatric head and neck cancer (PHNC) at a Brazilian institution, highlighting a lack of demographic information on these patients.
- A review of medical records from 1986 to 2016 revealed that 5.11% of pediatric cancer cases were malignant head and neck tumors, predominantly affecting white males aged 10-14, with the most common site being the neck and lymph nodes.
- Lymphomas were found to be the most prevalent type of PHNC, with Burkitt lymphoma and nodular sclerosis Hodgkin lymphoma being the most frequently diagnosed, indicating a shift in the types of cancers being diagnosed in this population.