Publications by authors named "Iva Dzhilyanova"
Nat Commun
September 2022
Article Synopsis
- Silencing of endogenous retroviruses (ERVs) involves repressive modifications—H3K9me3 and DNA methylation—primarily mediated by Setdb1 and Dnmt1.
- Conditional knock-out of Setdb1 in mouse embryonic endoderm leads to ERV de-repression in visceral endoderm descendants but not in definitive endoderm, indicating different pathways at play.
- Data reveal that DNA methylation is more crucial for silencing ERVs compared to H3K9me3, highlighting its dominance in maintaining ERV repression in endoderm cells.
