Publications by authors named "Iva Dundovic"
Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy.
Proc Natl Acad Sci U S A
November 2024
Article Synopsis
- The quality of female eggs is crucial to reproductive lifespan, heavily influenced by the presence of the right number of chromosomes (euploidy), with common errors in meiosis leading to egg aneuploidy.
- Researchers used a genetic biobank to identify 404 genes associated with higher rates of egg aneuploidy, highlighting the role of the kinesin protein family in this process.
- They demonstrated that specific genetic variants in kinesin genes can cause increased aneuploidy in mouse eggs and validated that certain variants accelerate reproductive aging, paving the way for potential noninvasive biomarkers to assess egg quality in fertility medicine.
Neurofibromin (Nf1) is a giant multidomain protein encoded by the tumour-suppressor gene NF1. NF1 is mutated in a common genetic disease, neurofibromatosis type I (NF1), and in various cancers. The protein has a Ras-GAP (GTPase activating protein) activity but is also connected to diverse signalling pathways through its SecPH domain, which interacts with lipids and different protein partners.
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- - The female reproductive lifespan is influenced by egg quality, particularly the condition of chromosomes in eggs (euploidy) versus abnormalities (aneuploidy).
- - Researchers analyzed genetic data from mothers to pinpoint 404 genes associated with high rates of egg aneuploidy, highlighting the role of kinesin protein family genes in this risk.
- - Experimental studies in mice confirmed that specific variants in kinesin genes lead to increased egg aneuploidy and faster reproductive aging, opening up possibilities for non-invasive egg quality assessments in fertility treatments.