[Crohn disease and psoriasis].

Clinical case of Crohn's disease diagnostics with psoriatic appearance of skin rash as the first manifestation described.

[State of the mouth cavity in patients with inflammatory intestinal diseases].

The article presents the results of the dental examination of 75 patients with ulcerative colitis and Crohn's disease with mild and medium-to-severe clinical course. Absolutely all of the patients had intensive dental caries and inflammatory diseases of the paradontium that exceeded the average statistical level for Moscow both in terms of incidence and severity. As many as 20-60% of patients suffering from inflammatory intestinal diseases also had such disorders of the mouth cavity mucous membrane as angular cheilitis, labial fissures, glossitis or aphthous stomatitis.

[Permeability of intestinal barrier fo macromolecules in patients with Crohn's disease and ulcerative colitis].

Ovalbumin loading enzyme immunoassay was made in 44 patients with ulcerative colitis (UC) and 8 patients with Crohn's disease (CD). Enhanced intestinal permeability for macromolecules was found in 87.5 and 65.

[Features of inflammation of the mucosa of the large intestine in nonspecific ulcerative colitis and Crohn's disease].

Histological, morphometric, and immunohistochemical studies (with detection of the local production of IgA, IgM, IgG, IgE, and IgD, secretory component of IgA, and deposition of the third complement component, C3) were carried out on biopsies of the colon mucosa from 66 patients with recurrent and continuous forms of nonspecific ulcerative colitis and 16 patients with Crohn's disease. Inflammation in the colon mucosa in the diseases under study was found to be accompanied by marked activation of the local immune system, increased local production of IgA and IgM as well as IgG, particularly in those parts of the mucosa which had no glands. Local synthesis of IgE and IgD also increases indicating allergic reaction in the mucosa alongside with tissue eosinophilia.