Impact of early and delayed Nd:YAG laser goniopuncture on results of deep sclerectomy (5-years follow up period).

Purpose: To report on impact of Nd:YAG laser goniopuncture (LGP) timing on hypotensive efficacy of deep sclerectomy (DS) for open-angle glaucoma (OAG) patients.

Methods: 228 patients who underwent DS followed by Nd:YAG LGP between January 2010 and December 2013, (follow up - 5 years) were enrolled into a single-center, retrospective, non-randomized, consecutive study. Subjects were divided into two groups (1 - delayed LGP,  = 116; 2 - early LGP,  = 112).

Comparison of the Intraocular Pressure-Lowering Efficacy and Safety of the Brinzolamide/Brimonidine Fixed-Dose Combination versus Concomitant Use of Brinzolamide and Brimonidine for Management of Open-Angle Glaucoma or Ocular Hypertension.

Objective: To demonstrate that the intraocular pressure (IOP)-lowering efficacy of a twice-daily brinzolamide 10 mg/mL (BRINZ)/brimonidine 2 mg/mL (BRIM) fixed-dose combination (BBFC) was non-inferior to its individual components (BRINZ+BRIM) dosed concomitantly in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Safety was also evaluated.

Methods And Analysis: This was a Phase III, multicenter, observer-masked study in patients from China, Russia and Taiwan.

Effect of pterygopalatine blockade on perioperative stress and inflammatory outcomes following paediatric cataract surgery.

Background: General anesthesia is required to perform pediatric cataract surgery. To reduce severity of surgical intervention and postoperative complications, regional techniques have been concomitantly used. The traditional regional ophthalmic techniques are retrobulbar, peribulbar and sub-Tenon blocks, which present some technical difficulties and associated complication risks.

[Nd:YAG laser goniopuncture as a mandatory adjuvant procedure after non-penetrating deep sclerectomy (long-term observation results)].

Unlabelled: Today, Nd:YAG laser goniopuncture (LGP) is considered a mandatory non-penetrating deep sclerectomy adjuvant procedure. However, its indications and timing remain debatable.

Purpose: To evaluate the effect of Nd:YAG laser goniopuncture on the long-term hypotensive effectiveness of non-penetrating deep sclerectomy.

[Complex assessment of retinal ischemic damage in patients with retinal vein occlusion].

Purpose: To evaluate the effectiveness of treatment and the possibility of restoring visual functions in patients with retinal vein occlusion (RVO) depending on the initial degree of macular ischemia.

Material And Methods: The study included 84 patients with RVO. The main inclusion criteria were the presence of macular edema in the setting of RVO with the duration of no more than 3 months and without any previous treatment.

Intraocular cytokines in retinal vein occlusion and its relation to the efficiency of anti-vascular endothelial growth factor therapy.

Purpose: To analyze the change in the concentration of intraocular cytokines (ICs) in patients with retinal vein occlusion (RVO) before and after intravitreal ranibizumab therapy (IVR), and to find the correlations of IC with clinical activity of RVO and efficiency of treatment.

Materials And Methods: Forty-four patients aged 46-79 years old (mean age: 60.7 ± 7.

[Comprehensive assessment of risk factors for retinal vein occlusion and derivation of classification criteria for retinal ischemia].

Objective: to perform a complex ophthalmological and general examination of patients with retinal vein occlusion (RVO) and to derive classification criteria for retinal ischemia.

Materials And Methods: A total of 44 patients with RVO and macular edema and 20 controls were enrolled. All patients underwent a thorough ophthalmological and general examination and clinical laboratory testing.

[Changes of intraocular cytokine level in patients with vascular and neovascular retinal pathology depending on pathologic process activity].

Cytokine and growth factors levels were estimated in anterior chamber humor of patients with different diseases manifesting with vascular and neovascular retinal changes and various pathologic process activity. 40 patients with macula edema, retinal and choroid neovascularization were examined. Process activity was determined based on data obtained using high-resolution optical coherence tomography and fluorescent angiography.

[Advances in radiotherapy of malignant tumours].

The authors discuss changes in the equipment and technologies of radiotherapy during the past 10-15 years. These changes ensured the improvement of diagnostics and treatment of neoplasms by two other main methods, surgical and medicamental. Modifications in the combined application of radiotherapy and surgery and of radio- and pharmacotherapy are discussed.

[Modern notions of regularities and mechanisms of formation of Frank-Kamenetskiy glaucoma].

Frank-Kamentsky glaucoma, a hereditary disease of the eyes, transmitted by female partners with X-linked type. It is accompanied by typical progressive lesions in the stroma and in the iridal pigment sheet at the background of goniodisgenesis. Males suffer from these diseases most frequently.

[Problems of radiation therapy of patients with malignant tumors and modern ways of resolving them].

At the present stage of radiation oncology, treatment successes are mainly determined by improvement of multimodality therapy that utilizes benefits of each modality in individual patients. Radiotherapy is mostly empiric, as demonstrated by dose fractionation. Its significance in many situations is underestimated, which leads to unreasonably excessive irradiation or, vice versa, to its unreasonable refusal.

[Treatment of local Hodgkin's disease with massive mediastinal involvement].

Aim: To define the scope of combined therapy in patients having local Hodgkin's disease (LHD) with massive mediastinal lesion.

Material And Methods: From 1980 to 1997 the treatment was given to 75 LHD patients with massive lesion of the mediastinum (mediastinal-thoracic index, MTI, > or = 0.33).

[The late results of the combined therapy of patients in 2nd-stage lymphogranulomatosis].

Aim: To define the scope of combined therapy according to prognostic factors in patients with Hodgkin's disease state II.

Materials And Methods: 98 patients with favorable and unfavorable Hodgkin's disease (HD) prognosis according to EORTC criteria (41 and 57 of group 1 and 2, respectively) entered the study. Unfavorable factors were: mixed HD variant and lymphoid depletion, ESR above 50 mm/h in stage A and 30 mm/h in stage B, involvement of more than 3 groups of lymph nodes, age over 40.

[Late results of the combined treatment of locally disseminated soft tissue sarcomas].

Radical surgery was performed in 69 cases of primary and recurrent localized soft-tissue sarcomas (extended dissection of tumor--53, exarticulation or amputation--16) after a course of non-uniform irradiation, when other methods of specific treatment had failed. Areas of exposed tumors were irradiated with focal doses of 90-120 Gy, screened areas--with 40-60 Gy. Radiation was delivered through a latticed diaphragm from the same field.