[Use of nebivolol in patients with mild and moderate hypertension].

Aim: To evaluate the effectiveness and safety of the beta-adrenoblocker nebivolol in patients with mild and moderate essential hypertension.

Material And Methods: The trial enrolled 20 patients. 11 of them had mild and 9 moderate arterial hypertension (mean age 47.

[Long-term ambulatory follow-up of hypertension patients with low renin activity in blood].

Aim: To characterize a clinical course of arterial hypertension in patients with low activity of blood renin.

Material And Methods: 44 hypertensive patients with low activity of blood renin participated in the trial. They were divided into three groups consisting of 18, 14 and 12 patients (group 1, 2 and 3 with adrenal adenoma, adrenal hyperplasia and hypertension, respectively).

[Characteristics of patients with arterial hypertension in Moscow (as exemplified by a municipal cardiological center)].

Aim: To characterize hypertensive patients, residents of Moscow, treated at Moscow Municipal Cardiological Center (MMCC) in 1999.

Material And Methods: A total of 1056 case histories of patients with the diagnosis of arterial hypertension or essential hypertension, directed to MMCC in 1999, were analyzed. The files were processed using specially developed standard methods.

[Treatment of patients with arterial hypertension in Moscow].

Aim: To analyze treatment for arterial hypertension in Moscow.

Material And Methods: 1056 case histories of hypertensive patients referred to Moscow city cardiological hospital in 1999 were analysed. The analysis covered the following issues: frequency of use of antihypertensive drugs depending on the disease stage; adequacy of the doses; changes in the treatment due to the presence of hypertrophy of the left ventricular myocardium, cardiac failure, vascular complications, diabetes mellitus.

[Platelet aggregation in patients with various forms of left ventricular hypertrophy and its changes at long-term follow-up and treatment].

Aim: To study platelet aggregation (PA) in patients with left ventricular hypertrophy (LVH) in essential hypertension (EH) and hypertrophic cardiomyopathy (HTCM), and to assess aspirin treatment effects.

Material And Methods: A general clinical examination, echocardiography, 24-h monitoring of ECG and arterial pressure, bicycle exercise, test for platelet aggregation, routine blood biochemical tests were performed in 30 males with EH and LVH, 30 males with HTCM and 10 healthy controls.

Results: It was found that the patients had high platelet sensitivity to aggregation inductors as well as high spontaneous aggregation.

[Five-year activity of new departments of emergency cardiological care with cardiac resuscitation units in Moscow].

Aim: To analyse results of treatment in new cardiological critical care units in Moscow (62 beds).

Material And Methods: Five years reports presented in 1993-1999 to Moscow Public Health Committee.

Results: The activity of the new cardiological units proved efficient: cardiovascular lethality reduced by 20%; quality of diagnosis and treatment improved; bed turnover increased.

[Platelet aggregation in patients with hypertrophic cardiomyopathy].

Aim: To examine correlation between platelet aggregation and the degree of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HC).

Material And Methods: Routine clinical examination, ECG, echo-CG, measurement of platelet aggregation, routine biochemical blood tests were made in 45 HC males and 15 healthy controls.

Results: HC patients were characterized with high induced and spontaneous platelet aggregation which increased with left ventricular myocardial mass.

[Myocardial hypertrophy and coronary insufficiency as a cause of arrhythmia in patients with hypertension].

Aim: To elucidate contribution of left ventricular hypertrophy (LVH) vs myocardial ischemia to rhythmic disorders in patients with essential hypertension (EH) and LVH.

Materials And Methods: Echocardiography, coronarography, treadmill test, 24-h ECG monitoring were included in examination of 69, 69, 68 and 63 patients, respectively. All of them had EH stage II and LVH.

[Late ventricular potentials in left ventricular hypertrophy in patients with stage-II hypertension].

Aim: To evaluate diagnostic significance of high-resolution ECG in patients with blood hypertension (BH) stage II with left ventricular hypertrophy (LVH) in the presence or absence of angiographically verified atherosclerosis of the coronary arteries.

Materials And Methods: ECG (registration of late ventricular potentials by M. Simson and R.

[Efficacy of moxonidine, an imidazoline receptor agonist, in patients with essential hypertension].

Aim: Study of zint (moxonidine), a hypotensive drug with the central mechanism of action.

Materials And Methods: The hemodynamics and platelet functional activity were assessed in 30 patients with essential hypertension treated by zint in a daily dose of 0.4 mg, taken in the morning, for 3 months.

[The treatment of hypertension patients with Estulic].

Estulic, a hypotensive drug of a central mechanism of action, has been tried for effect on hemodynamics, coronary circulation and platelet functional activity in 30 patients with essential hypertension. The findings at tonometry, echoCG, treadmill exercise, platelet aggregation were indicative of a fall in both diastolic and systolic pressure associated with decreased platelet aggregation.

[Comparative analysis of the parameters of left ventricular systolic and diastolic functions in patients with hypertension and patients with hypertrophic cardiomyopathy].

17 patients with essential hypertension and asymmetric, 12 ones with concentric left ventricular (LV) hypertrophy and 13 patients with asymmetric hypertrophic cardiomyopathy (HCM) were examined by M-mode and Doppler echocardiography. There were significant changes of LV diastolic volumes, mitral flow velocities and phase duration in all groups of patients compared to healthy subjects. Nevertheless, the hypertensive groups had noninvolved LV systolic function.

[Anomalous chordae tendineae].

ECG of 322 patients with various cardiovascular diseases allowed the conclusion on the occurrence of anomalous chordae of the heart in 21.7% of cases. The chordae had no effect on the disease diagnosis, running, hemodynamics, left ventricular myocardial mass.

[The functional characteristics of the thrombocytes in patients with hypertension and "silent" myocardial ischemia].

Functional platelet characteristics were studied in hypertensive subjects having episodes of silent myocardial ischemia. A total of 36 patients with essential hypertension (EH) stage II (WHO criteria, 1979) underwent echocardiography and 24-h ECG monitoring. Platelet aggregation induced by adenosine diphosphate was assessed by laser aggregation analyzer.

[A method for determining individual nifedipine sensitivity in treating hypertension patients].

Nifedipine antihypertensive effect was evaluated in 20 patients with essential hypertension. It was found to depend on pretreatment values of ADP-induced platelet aggregation response. The latter was studied with a new method of laser measurements of the aggregate radius sizes.

[The risk assessment for a fatal outcome in patients with stable angina based on the data from a long-term prospective observation (a comparison of the 5-year survival prognosis with the data at the 6th to 12th years of the observation)].

A rule has been developed to predict coronary death in 377 patients with coronary heart disease and stable angina due to coronary stenotic atherosclerosis. Gravimetric values of various clinical signs, resting ECG changes, and bicycle ergometric testing have been obtained by a computer. A decisive rule has been also derived.

[Atrial disorders of the heart rhythm in hypertension].

A total of 57 males with stage-II hypertensive disease were studied to diagnose latent atrial disturbances of cardiac rhythm. Holter monitoring showed that latent atrial arrhythmias were diagnosed in 82.4% of patients.

[Plasma beta-endorphin level in "silent" myocardial ischemia during Holter ECG monitoring].

The results from recent studies suggest that the endogenous opioid beta-endorphin (beta-E) is related to pain modulation. Therefore, plasma beta-E levels were studied in 23 patients with essential hypertension (EH) and in 7 patients with coronary artery disease (CAD) during asymptomatic ischemic events and in 5 patients with CAD during symptomatic ischemic events. Blood samples for beta-E were taken at the moment of silent ST depression, pointed with alarm by the real time ECG monitor "Q Med Monitor" (USA).

[Silent myocardial ischemia in patients with essential hypertension].

Holter monitoring was performed in 61 patients with essential hypertension. Painless, silent ST segment depression was found in 34 patients. Exercise myocardial scintigraphy indicated the occurrence of transient perfusion defects without abnormal clearance (Group 1) and those with abnormal clearance (Group 2).

[Comparison between seasonal changes in lipid indicators in patients with post-infarction cardiosclerosis and arterial hypertension in Ashkhabad and Moscow].

The study was undertaken to examine 190 males, aged 30-60 years who were divided into 4 groups: (1) patients with essential hypertension; (2) those with postinfarction cardiosclerosis; (3) those with postinfarction cardiosclerosis and essential hypertension; (4) healthy individuals. The levels of apolipoproteins B and A1 and circulating immune complex cholesterol were examined in the cold (winter) and hot (summer) seasons in the areas of arid (Ashkhabad) and temperate (Moscow) climate. The major apo-proteins were determined by enzyme uncompetitive immunoassay.