[On the applied medicolegal significance of the notion of "medical error"].

The current practice of expertise of the adequacy of organization of the provision of medical aid introduces a new aspect of the notion of "medical error" that is widely employed in medical profession, among lawyers, patients, and their relatives as well as in mass media. The universally accepted meaning of this notion has not thus far been proposed. The authors consider the medico-legal concept of "medical error" reconciling the contradictory opinions.

[The peculiarities of serum levels of S100b protein and antibodies to it in patients with crisis and stable essential hypertension].

The article covers the results of research into the levels of S100b protein and antibodies to it in the serum of patients with crisis and stable essential hypertension. The results show that neutrophic protein dysmetabolism plays an important role in the pathogenesis of hypertonic dyscirculatory encephalopathy and the forming of cognitive disorder syndrome. The data obtained suggest that hypertensive crises lead to pathologic changes in hematoencephalic barrier permeability and the development of autoimmune reactions with participation of neutrophic proteins.

[Biochemical markers of apoptosis in different brain regions after training].

Activity of caspase-3 and content of DNA fragments with sizes 0.2-0.6 kbp and more than 4.

[Protein HLDF and antibodies to it as molecular pathogenetic factors and new markers of acute cerebral blood circulation disturbances].

Clinic-experimental complex investigation and ELISA determination of protein HLDF as also primary antibodies (Abs) to HLDF values in blood and cerebro-spinal fluid (CSF) of patients with hypertensive crises and acute aterotrombotic ischemic stroke were performed. Statistically improved difference in serum HLDF and Abs content in examined patients in comparison with age-matched controls as also significant intergroup's differences in protein and Abs dynamic content were determined. Correlation between content and dynamics of investigated factors in CSF and blood serum with determined clinical and instrumental parameters was revealed.

[Etalon-free laser mass-spectrometry as a new method of the elementary analysis of bone tissue at identification].

The results of an experimental study dealing with the elementary composition of bone tissue by using the method of laser mass spectrometry are described in the paper. The method ensures the quantification of concentration values of all elements from the Mendeleev periodic table that can be made within an extensive dynamic range, which makes it promising in the forensic medical identification.

[Concentrating dopamine in liposomes using transmembrane gradient of ammonium sulfate].

The active loading of liposomes from egg phosphatidylcholine and cholesterol with dopamine using an ammonium sulfate gradient was studied. Our conditions allowed the enrichment of the monolamellar liposomes with 90% dopamine added to the medium and, thus, considerably improve the dopamine/lipid ratio. Dopamine-containing liposomes with tocopherol in their lipid bilayer were shown to be stable for 3 weeks.

[Oxidation in liposomes from egg phosphatidylcholine loaded with L-3,4-dihydroxyphenylalanine (DOPA) and dopamine: mutual effect of components].

Oxidation of egg phosphatidylcholine and catechols (L-3,4-dihydroxyphenylalanine or dopamine) in liposome dispersions was studied. These catechols, encapsulated in liposomes, were shown to decrease the rate of phosphatidylcholine oxidation by factors of 4.9 and 2.

[Physico-chemical properties of liposome forms of L-3,4-dihydroxyphenylalanine (DOPA) and dopamine].

L-3,4-Dihydroxyphenylalanine (DOPA) and dopamine encapsulated in liposomes have been obtained. These preparations can be used as drugs for Parkinson's disease. The level of encapsulation of the compounds under study in liposomes and their partition coefficients have been determined.

[Interrelationship between pro-oxidant and immunomodulating properties of vitamin D].

It was shown in experiments on mice that 1.25 (OH)2D3 ingested per os in dose 100 ng during 5 days caused the great increasing of lipid peroxidation (LP) in peritoneal macrophages and spleen cells. The evidence of LP induction is the production of TBA-positive substances in these cells.

[Prognosis of work capacity in the system of rehabilitation of patients with myocardial infarct].

The possibilities of prognosing with regard to the capacity for work within the 1st year of resuming working were studied in the system of rehabilitation of myocardial infarction patients. The prognostic value of several items was determined that characterize the state of the patient prior to his myocardial infarction, the course of the acute phase, and the state in the postinfarction period prior to resuming working. The informativeness of several sets of items was determined along with the relative informativeness of a certain single item, with that of a group of other items known.

State and perspectives of development of rehabilitation trends in cardiology.

On the basis of the experience of rehabilitation of 500 myocardial infarction patients recommendations are given for the development of rehabilitation in cardiology. It is indicated that the problems of rehabilitation should be solved with the participation of the existing medical establishments, i. e.

[Tactical characteristics of physical rehabilitation of patients after myocardial infarct].

A study of the dynamics of the electrocardiographic, hemodynamic and cardiodynamic indices in patients who survived myocardial infarction showed that a specially compiled programme of physical rehabilitation for such patients corresponded in terms of the tempo of load increase to the normalization of these parameters. The leading tactical principle of this programme, that consists in an early activization of the patient in bed and a relatively unhastened transit to active movements in an upright position, may be recommended for a wide practical implementation as the most physiologically grounded.