Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia.

Objective:  We examined the interaction of polymorphisms in the genes heme oxygenase-1 () and nitric oxide synthase () in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy.

Methods:  The genes (rs2071746, A/T) and (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 HO-1) were measured using enzyme-linked immunosorbent assay (ELISA).

Results:  We found interactions between genotypes of the and genes and responsiveness to methyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA.