Publications by authors named "Iuliu Cezar Zainescu"
Design, synthesis, and evaluation of venom serine protease peptidic inhibitors.
Gloria Maria da Silva Daniel Henrique Berto de Souza Karoline B Waitman Matteo Celano Ebram Melissa R Fessel Iuliu Cezar Zainescu
J Venom Anim Toxins Incl Trop Dis
January 2021
Article Synopsis
- In Central and South America, snakebite envenomation is primarily caused by Bothrops spp. snakes, whose venom contains harmful serine proteases that current antivenoms don't fully neutralize.
- Researchers designed 6-mer peptides specifically to inhibit these venom serine proteases, aiming to enhance the effectiveness of antivenoms.
- They identified two promising inhibitor peptides, one of which showed potential in selectively inhibiting the venom's serine proteases without affecting human proteases, suggesting a new avenue for improving treatment for snakebites.