Publications by authors named "Iulia-Andrea Zsoldos"
Article Synopsis
- Macrophage activation syndrome (MAS) is a serious inflammatory condition that can arise from various sources like infections or autoimmune diseases, but it is often misdiagnosed as sepsis or other complications.
- Effective early diagnosis is crucial, as many patients miss out on timely treatment, leading to high mortality rates.
- This review analyzes 40 studies to identify key diagnostic criteria for MAS, highlighting symptoms like fever and hyperferritinemia, and anticipates a comprehensive diagnostic score from a current international consensus effort, the Delphi International Survey.
Background And Aims: Chelating agents therapy is recommended for polytransfused patients that have evidence of iron overload (an elevated serum ferritin or received over 20 units of red blood cell transfusions). Deferasirox showed efficacy and safety in maintaining or reducing body iron. Iron chelation therapy was associated with hematopoiesis improvement in transfusion-dependent patients.
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